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Chemical Compound Review

STOCK4S-00641     (3Z)-7-(3-methylphenyl)-3- [(4...

Synonyms: STK705000, ZINC02351777, AKOS001674385, AC1M023Y, MolPort-000-465-123
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Disease relevance of ZINC02351777


High impact information on ZINC02351777

  • DNA sequence at the integration sites of the insertion element IS1 [6].
  • Promotion of RNA transcription on the insertion element IS30 of E. coli K12 [7].
  • The microevolution of Y. pestis was therefore investigated by three different multilocus molecular methods, targeting genomewide synonymous SNPs, variation in number of tandem repeats, and insertion of IS100 insertion elements [8].
  • Control of expression of a cloned yeast (Saccharomyces cerevisiae) gene (trp5) by a bacterial insertion element (IS2) [9].
  • In a departure from these earlier studies, we used three tagging markers (A-5466C, T-3892C, and Ins/Del) at the ACE locus to test for disease haplotype associations [10].

Chemical compound and disease context of ZINC02351777


Biological context of ZINC02351777

  • Plasmid expression experiments using lc-nmpC hybrid genes show that it is the presence of the IS5 insertion which prevents expression of the porin in wild-type E. coli K12 [16].
  • These mutants express the fucO gene constitutively, as a result of an IS5 insertion in the promoter region [17].
  • This insertion deletes 18 residues from the COOH terminus of NmpC protein and adds 8 residues from an open reading frame extending into IS5 sequence [16].
  • We have located the toxin genes of S. dysenteriae 1 to a region homologous to minute 30 of the E. coli chromosome, within a 22.4 kbp putative composite transposon bracketed by IS600 insertion sequences [18].
  • Mapping of RNA polymerase binding sites in R12 derived plasmids carrying the replication-incompatibility region and the insertion element IS1 [19].

Anatomical context of ZINC02351777

  • The 16S rRNA test was able to detect 10(7) bacteria per g of feces, and the IS900 test detected 10(4) to 10(5) per g of feces [20].
  • This gene requires a promoter, ribosome binding site (RBS) and termination codon to be acquired upon insertion into the M. avium subsp. paratuberculosis genome and hence is designated the hed (host expression-dependent) gene of IS900 [21].
  • The sensitivity of IS900 TaqMan was 1 colony-forming unit (CFU) for M. a. paratuberculosis ATCC 19698 [22].
  • Real-time PCR with a fluorescent probe targeting the insertion element IS900 detected as few as 10 organisms per sample of 100 mul semen [23].
  • IS900 TaqMan was also useful in the study of growth characteristics of 3 groups of M. a. paratuberculosis strains in bovine fecal samples from 3 shedding levels (heavy, medium, and low) based on cell numbers measured by Herrold egg yolk (HEY) agar culture [22].

Associations of ZINC02351777 with other chemical compounds


Gene context of ZINC02351777

  • Blot hybridization detected no mRNA transcripts from the wild-type nmpC gene, although transcripts were readily detected from the lc gene in PA-2 lysogens and from the nmpC mutant which has excised the IS5 [16].
  • Furthermore, we analyzed another known common single-base-pair insertion/deletion polymorphism (ins/del allele) found in the promoter region of the PAI-1 gene and thought to be of functional importance in regulating PAI-1 gene expression [28].
  • UV induction of IS10 transposition did not depend on the umuC and uvrA gene product, but it was not observed in lexA3 and DeltarecA strains, indicating that the SOS stress response is involved in regulating UV-induced transposition [29].
  • DNA sequences flanking an E. coli insertion element IS2 in a cloned yeast TRP5 gene [30].
  • CfcA11 has a mutation in glySa which encodes the alpha-subunit of glycyl-tRNA synthetase, and cfcB1 has an IS2 insertion in apaH which encodes Ap4A hydrolase [31].

Analytical, diagnostic and therapeutic context of ZINC02351777

  • In vivo oligomerization of IE1 was verified by immunoprecipitation of IE1 complexes from extracts of plasmid-transfected SF21 cells [24].
  • Cloning and analysis of PCR products showed that different bla(SHV) variants existed in cis with individual promoters in individual isolates but that mutant genes were more abundant downstream of the IS26 promoter [32].
  • ISRm4, an IS-like sequence structurally similar to Pseudomonas cepacia insertion element IS402, was identified by sequence analysis [33].
  • To determine the sites of IS1 insertion, pWR127 DNAs extracted from 95 independently isolated Vi- strains were analyzed by digestion with the restriction endonuclease PstI and agarose gel electrophoresis [34].
  • Two strains of M. avium containing the DNA insertion element IS901 (M. avium+) and two strains not containing this element (M. avium-) were inoculated subcutaneously or by oral administration into guinea pigs to assess their virulence in these animals and their ability to induce delayed type hypersensitivity to tuberculins [35].


  1. Insertion of IS2 creates a novel ampC promoter in Escherichia coli. Jaurin, B., Normark, S. Cell (1983) [Pubmed]
  2. The sequence of the bacteriophage P1 genome region serving as hot target for IS2 insertion. Sengstag, C., Shepherd, J.C., Arber, W. EMBO J. (1983) [Pubmed]
  3. Selective cloning of Bacillus subtilis xylose isomerase and xylulokinase in Escherichia coli genes by IS5-mediated expression. Wilhelm, M., Hollenberg, C.P. EMBO J. (1984) [Pubmed]
  4. Nonconsensus intronic mutations cause episodic ataxia. Wan, J., Carr, J.R., Baloh, R.W., Jen, J.C. Ann. Neurol. (2005) [Pubmed]
  5. Specific detection of Mycobacterium paratuberculosis by DNA hybridisation with a fragment of the insertion element IS900. Moss, M.T., Green, E.P., Tizard, M.L., Malik, Z.P., Hermon-Taylor, J. Gut (1991) [Pubmed]
  6. DNA sequence at the integration sites of the insertion element IS1. Calos, M.P., Johnsrud, L., Miller, J.H. Cell (1978) [Pubmed]
  7. Promotion of RNA transcription on the insertion element IS30 of E. coli K12. Dalrymple, B., Arber, W. EMBO J. (1985) [Pubmed]
  8. Microevolution and history of the plague bacillus, Yersinia pestis. Achtman, M., Morelli, G., Zhu, P., Wirth, T., Diehl, I., Kusecek, B., Vogler, A.J., Wagner, D.M., Allender, C.J., Easterday, W.R., Chenal-Francisque, V., Worsham, P., Thomson, N.R., Parkhill, J., Lindler, L.E., Carniel, E., Keim, P. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  9. Control of expression of a cloned yeast (Saccharomyces cerevisiae) gene (trp5) by a bacterial insertion element (IS2). Walz, A., Ratzkin, B., Carbon, J. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  10. A disease haplotype for advanced nephropathy in type 2 diabetes at the ACE locus. Ng, D.P., Placha, G., Choo, S., Chia, K.S., Warram, J.H., Krolewski, A.S. Diabetes (2006) [Pubmed]
  11. Recombination sites in plasmid drug resistance gene amplification. Peterson, B.C., Rownd, R.H. J. Bacteriol. (1985) [Pubmed]
  12. Transition of deletion mutants of the composite resistance plasmid NR1 in Escherichia coli and Salmonella typhimurium. Huffman, G.A., Rownd, R.H. J. Bacteriol. (1984) [Pubmed]
  13. Effect of mutations in the RNA polymerase gene and that of the transcription termination factor rho on expression of the Escherichia coli galactose operon with an IS2 polar insertion. Yarulin, V.R., Gorlenko, Z.M. Mol. Gen. Genet. (1985) [Pubmed]
  14. The isolation of fumB mutants of Escherichia coli. Henson, J.M., Blake, N.K., Marek, L.E. J. Gen. Microbiol. (1987) [Pubmed]
  15. Role of NAD(P)H:quinone oxidoreductase encoded by drgA gene in reduction of exogenous quinones in cyanobacterium Synechocystis sp. PCC 6803 cells. Elanskaya, I.V., Grivennikova, V.G., Groshev, V.V., Kuznetsova, G.V., Semina, M.E., Timofeev, K.N. Biochemistry Mosc. (2004) [Pubmed]
  16. Structure of the lc and nmpC outer membrane porin protein genes of lambdoid bacteriophage. Blasband, A.J., Marcotte, W.R., Schnaitman, C.A. J. Biol. Chem. (1986) [Pubmed]
  17. Evolution of an Escherichia coli protein with increased resistance to oxidative stress. Lu, Z., Cabiscol, E., Obradors, N., Tamarit, J., Ros, J., Aguilar, J., Lin, E.C. J. Biol. Chem. (1998) [Pubmed]
  18. Spontaneous tandem amplification and deletion of the shiga toxin operon in Shigella dysenteriae 1. McDonough, M.A., Butterton, J.R. Mol. Microbiol. (1999) [Pubmed]
  19. Mapping of RNA polymerase binding sites in R12 derived plasmids carrying the replication-incompatibility region and the insertion element IS1. Chan, P.T., Lebowitz, J. Nucleic Acids Res. (1982) [Pubmed]
  20. Evaluation of the abilities of three diagnostic tests based on the polymerase chain reaction to detect Mycobacterium paratuberculosis in cattle: application in a control program. van der Giessen, J.W., Haring, R.M., Vauclare, E., Eger, A., Haagsma, J., van der Zeijst, B.A. J. Clin. Microbiol. (1992) [Pubmed]
  21. IS900 targets translation initiation signals in Mycobacterium avium subsp. paratuberculosis to facilitate expression of its hed gene. Doran, T., Tizard, M., Millar, D., Ford, J., Sumar, N., Loughlin, M., Hermon-Taylor, J. Microbiology (Reading, Engl.) (1997) [Pubmed]
  22. Development and application of quantitative polymerase chain reaction assay based on the ABI 7700 system (TaqMan) for detection and quantification of Mycobacterium avium subsp. paratuberculosis. Kim, S.G., Shin, S.J., Jacobson, R.H., Miller, L.J., Harpending, P.R., Stehman, S.M., Rossiter, C.A., Lein, D.A. J. Vet. Diagn. Invest. (2002) [Pubmed]
  23. Sensitive detection of Mycobacterium avium subsp. paratuberculosis in bovine semen by real-time PCR. Herthnek, D., Englund, S., Willemsen, P.T., Bölske, G. J. Appl. Microbiol. (2006) [Pubmed]
  24. Oligomerization mediated by a helix-loop-helix-like domain of baculovirus IE1 is required for early promoter transactivation. Olson, V.A., Wetter, J.A., Friesen, P.D. J. Virol. (2001) [Pubmed]
  25. The effects of the apolipoprotein B signal peptide (ins/del) and XbaI polymorphisms on plasma lipid responses to dietary change. Pajukanta, P.E., Valsta, L.M., Aro, A., Pietinen, P., Heliö, T., Tikkanen, M.J. Atherosclerosis (1996) [Pubmed]
  26. Detection of Mycobacterium tuberculosis in clinical samples by using polymerase chain reaction and a nonradioactive detection system. Kolk, A.H., Schuitema, A.R., Kuijper, S., van Leeuwen, J., Hermans, P.W., van Embden, J.D., Hartskeerl, R.A. J. Clin. Microbiol. (1992) [Pubmed]
  27. Transposase-dependent formation of circular IS256 derivatives in Staphylococcus epidermidis and Staphylococcus aureus. Loessner, I., Dietrich, K., Dittrich, D., Hacker, J., Ziebuhr, W. J. Bacteriol. (2002) [Pubmed]
  28. Mutational analysis of the genes encoding urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in advanced ovarian cancer. Türkmen, B., Schmitt, M., Schmalfeldt, B., Trommler, P., Hell, W., Creutzburg, S., Graeff, H., Magdolen, V. Electrophoresis (1997) [Pubmed]
  29. UV light induces IS10 transposition in Escherichia coli. Eichenbaum, Z., Livneh, Z. Genetics (1998) [Pubmed]
  30. DNA sequences flanking an E. coli insertion element IS2 in a cloned yeast TRP5 gene. Brosius, J., Walz, A. Gene (1982) [Pubmed]
  31. Diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) controls the timing of cell division in Escherichia coli. Nishimura, A., Moriya, S., Ukai, H., Nagai, K., Wachi, M., Yamada, Y. Genes Cells (1997) [Pubmed]
  32. bla(SHV) Genes in Klebsiella pneumoniae: different allele distributions are associated with different promoters within individual isolates. Hammond, D.S., Schooneveldt, J.M., Nimmo, G.R., Huygens, F., Giffard, P.M. Antimicrob. Agents Chemother. (2005) [Pubmed]
  33. Sequence of ISRm4 from Rhizobium meliloti strain GR4. Soto, M.J., Zorzano, A., Olivares, J., Toro, N. Gene (1992) [Pubmed]
  34. Role of IS1 in the conversion of virulence (Vi) antigen expression in Enterobacteriaceae. Ou, J.T., Huang, C.J., Houng, H.S., Baron, L.S. Mol. Gen. Genet. (1992) [Pubmed]
  35. The efficacy of live tuberculosis vaccines after presensitization with Mycobacterium avium. de Lisle, G.W., Wards, B.J., Buddle, B.M., Collins, D.M. Tuberculosis (Edinburgh, Scotland) (2005) [Pubmed]
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