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Chemical Compound Review

ARBRIN     2-amino-3-(1-methylindol-3- yl)propanoic acid

Synonyms: ARBRIN,(L), SureCN19992, CHEMBL513172, AG-E-85660, ACMC-20a4ge, ...
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Disease relevance of NSC77678


High impact information on NSC77678


Associations of NSC77678 with other chemical compounds


Gene context of NSC77678

  • However, when 1-methyltryptophan replaces tryptophan as the inducer in this medium, mutations in both mtr and tnaB are required to prevent maximum induction [9].
  • An alternate inducer that is poorly cleaved by tryptophanase, 1-methyltryptophan, induces efficiently at low concentrations in both tna+ strains and tna mutants [9].


  1. Influenza-induced expression of indoleamine 2,3-dioxygenase enhances interleukin-10 production and bacterial outgrowth during secondary pneumococcal pneumonia. van der Sluijs, K.F., Nijhuis, M., Levels, J.H., Florquin, S., Mellor, A.L., Jansen, H.M., van der Poll, T., Lutter, R. J. Infect. Dis. (2006) [Pubmed]
  2. Indoleamine 2,3-dioxygenase (IDO) is involved in promoting the development of anterior chamber-associated immune deviation. Chen, X., Liu, L., Yang, P., Wu, C., Jin, H., Xing, L., Li, B., Zhou, H., Huang, X., Zhu, L. Immunol. Lett. (2006) [Pubmed]
  3. 4-1BB-mediated immunotherapy of rheumatoid arthritis. Seo, S.K., Choi, J.H., Kim, Y.H., Kang, W.J., Park, H.Y., Suh, J.H., Choi, B.K., Vinay, D.S., Kwon, B.S. Nat. Med. (2004) [Pubmed]
  4. IL-8 and IDO Expression by Human Gingival Fibroblasts via TLRs. Mahanonda, R., Sa-Ard-Iam, N., Montreekachon, P., Pimkhaokham, A., Yongvanichit, K., Fukuda, M.M., Pichyangkul, S. J. Immunol. (2007) [Pubmed]
  5. Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation. Hwu, P., Du, M.X., Lapointe, R., Do, M., Taylor, M.W., Young, H.A. J. Immunol. (2000) [Pubmed]
  6. Hydrophobic effect and hydrogen bonds account for the improved activity of a complement inhibitor, compstatin. Katragadda, M., Magotti, P., Sfyroera, G., Lambris, J.D. J. Med. Chem. (2006) [Pubmed]
  7. Roles of the tnaC-tnaA spacer region and Rho factor in regulating expression of the tryptophanase operon of Proteus vulgaris. Kamath, A.V., Yanofsky, C. J. Bacteriol. (1997) [Pubmed]
  8. Interferon-gamma independent oxidation of melatonin by macrophages. Rodrigues, M.R., Rodriguez, D., Henrique Catalani, L., Russo, M., Campa, A. J. Pineal Res. (2003) [Pubmed]
  9. Physiological studies of tryptophan transport and tryptophanase operon induction in Escherichia coli. Yanofsky, C., Horn, V., Gollnick, P. J. Bacteriol. (1991) [Pubmed]
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