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Gene Review

pstA  -  phosphate ABC transporter permease

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3719, JW3704, R2pho, phoR2b, phoT
 
 
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Disease relevance of pstA

  • Together with the previously isolated M. tuberculosis gene similar to the E. coli pstA, these are included in a cluster encoding a second putative phosphate transport system [1].
 

High impact information on pstA

  • The complete sequence is transcribed counterclockwise, in the order phoS pstC pstA pstB phoU [2].
  • It was concluded that the three genes pstA, pstB, and phoT were part of an operon and that the phosphate-binding protein was not coded for by any of these genes [3].
  • The gene order was concluded to be pstA-(pstB-phoT)-phoS, with the pstA gene promotor proximal and the direction of transcription opposite to that of the nearby unc operon [3].

References

  1. Identification of a second Mycobacterium tuberculosis gene cluster encoding proteins of an ABC phosphate transporter. Braibant, M., Lefèvre, P., de Wit, L., Ooms, J., Peirs, P., Huygen, K., Wattiez, R., Content, J. FEBS Lett. (1996) [Pubmed]
  2. Phosphate-specific transport system of Escherichia coli: nucleotide sequence and gene-polypeptide relationships. Surin, B.P., Rosenberg, H., Cox, G.B. J. Bacteriol. (1985) [Pubmed]
  3. Genetic analysis of mutants affected in the Pst inorganic phosphate transport system. Cox, G.B., Rosenberg, H., Downie, J.A., Silver, S. J. Bacteriol. (1981) [Pubmed]
 
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