Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

tatB - TatABCE protein translocation system subunit

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3831, JW5580, mttA2, ysgB

Sargent, F. et al., Bogsch, E.G. et al., Sargent, F. et al., De Buck, E. et al.

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Disease relevance of tatB

This conclusion is supported by the observation that Helicobacter pylori tatA will complement an E. coli tatA mutant, but not a tatB mutant [1].

High impact information on tatB

A mutation previously assigned to the hcf106 homologue encoded at the tatABCD locus, mttA, lies instead in the tatB gene [2].
The system probably functions in a similar manner to a Sec-independent translocase in the thylakoid membrane, and substrates for both systems bear a characteristic twin-arginine motif in the targeting peptide [3].

Biological context of tatB

The tatA and tatB genes were shown to constitute an operon while tatC is monocistronic [4].

References

Sec-independent protein translocation in Escherichia coli. A distinct and pivotal role for the TatB protein. Sargent, F., Stanley, N.R., Berks, B.C., Palmer, T. J. Biol. Chem. (1999) [Pubmed]
Overlapping functions of components of a bacterial Sec-independent protein export pathway. Sargent, F., Bogsch, E.G., Stanley, N.R., Wexler, M., Robinson, C., Berks, B.C., Palmer, T. EMBO J. (1998) [Pubmed]
An essential component of a novel bacterial protein export system with homologues in plastids and mitochondria. Bogsch, E.G., Sargent, F., Stanley, N.R., Berks, B.C., Robinson, C., Palmer, T. J. Biol. Chem. (1998) [Pubmed]
A putative twin-arginine translocation pathway in Legionella pneumophila. De Buck, E., Lebeau, I., Maes, L., Geukens, N., Meyen, E., Van Mellaert, L., Anné, J., Lammertyn, E. Biochem. Biophys. Res. Commun. (2004) [Pubmed]

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