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Gene Review:

tatA - TatABCE protein translocation system subunit

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3830, JW3813, mttA1, yigT

Weiner, J.H. et al., Sargent, F. et al., Sargent, F. et al., Wexler, M. et al.

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Disease relevance of tatA

This conclusion is supported by the observation that Helicobacter pylori tatA will complement an E. coli tatA mutant, but not a tatB mutant [1].

High impact information on tatA

A pleiotropic-negative mutant in mttA prevents the periplasmic localization of twin arginine redox enzymes, including nitrate reductase (NapA) and trimethylamine N-oxide reductase (TorA) [2].
A mutation previously assigned to the hcf106 homologue encoded at the tatABCD locus, mttA, lies instead in the tatB gene [3].
Features of the tatA operon that may control TatD expression are discussed [4].

References

Sec-independent protein translocation in Escherichia coli. A distinct and pivotal role for the TatB protein. Sargent, F., Stanley, N.R., Berks, B.C., Palmer, T. J. Biol. Chem. (1999) [Pubmed]
A novel and ubiquitous system for membrane targeting and secretion of cofactor-containing proteins. Weiner, J.H., Bilous, P.T., Shaw, G.M., Lubitz, S.P., Frost, L., Thomas, G.H., Cole, J.A., Turner, R.J. Cell (1998) [Pubmed]
Overlapping functions of components of a bacterial Sec-independent protein export pathway. Sargent, F., Bogsch, E.G., Stanley, N.R., Wexler, M., Robinson, C., Berks, B.C., Palmer, T. EMBO J. (1998) [Pubmed]
TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export. Wexler, M., Sargent, F., Jack, R.L., Stanley, N.R., Bogsch, E.G., Robinson, C., Berks, B.C., Palmer, T. J. Biol. Chem. (2000) [Pubmed]

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