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Gene Review

tatA  -  TatABCE protein translocation system subunit

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3830, JW3813, mttA1, yigT
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Disease relevance of tatA


High impact information on tatA

  • A pleiotropic-negative mutant in mttA prevents the periplasmic localization of twin arginine redox enzymes, including nitrate reductase (NapA) and trimethylamine N-oxide reductase (TorA) [2].
  • A mutation previously assigned to the hcf106 homologue encoded at the tatABCD locus, mttA, lies instead in the tatB gene [3].
  • Features of the tatA operon that may control TatD expression are discussed [4].


  1. Sec-independent protein translocation in Escherichia coli. A distinct and pivotal role for the TatB protein. Sargent, F., Stanley, N.R., Berks, B.C., Palmer, T. J. Biol. Chem. (1999) [Pubmed]
  2. A novel and ubiquitous system for membrane targeting and secretion of cofactor-containing proteins. Weiner, J.H., Bilous, P.T., Shaw, G.M., Lubitz, S.P., Frost, L., Thomas, G.H., Cole, J.A., Turner, R.J. Cell (1998) [Pubmed]
  3. Overlapping functions of components of a bacterial Sec-independent protein export pathway. Sargent, F., Bogsch, E.G., Stanley, N.R., Wexler, M., Robinson, C., Berks, B.C., Palmer, T. EMBO J. (1998) [Pubmed]
  4. TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export. Wexler, M., Sargent, F., Jack, R.L., Stanley, N.R., Bogsch, E.G., Robinson, C., Berks, B.C., Palmer, T. J. Biol. Chem. (2000) [Pubmed]
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