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Gene Review:

tatC - TatABCE protein translocation system subunit

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3832, JW3815, mttB, yigU, yigV

Blaudeck, N. et al., Bogsch, E.G. et al., Ize, B. et al.

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Disease relevance of tatC

This export was inhibited by carbonyl cyanide m-chlorophenylhydrazone, but not by sodium azide, and was blocked in E. coli tatC and tatAE mutant strains, showing that membrane translocation of the TorA-GFOR fusion protein occurred via the Tat pathway and not via the Sec pathway [1].

High impact information on tatC

The gene has been designated tatC (for twin-arginine translocation), and we show that homologous genes are present in a range of bacteria, plastids, and mitochondria [2].
In contrast, the deletion of the tatC gene blocked RR-ColV in the cytoplasm and this strain exhibited a normal growth phenotype [3].

References

Specificity of signal peptide recognition in tat-dependent bacterial protein translocation. Blaudeck, N., Sprenger, G.A., Freudl, R., Wiegert, T. J. Bacteriol. (2001) [Pubmed]
An essential component of a novel bacterial protein export system with homologues in plastids and mitochondria. Bogsch, E.G., Sargent, F., Stanley, N.R., Berks, B.C., Robinson, C., Palmer, T. J. Biol. Chem. (1998) [Pubmed]
In vivo dissection of the Tat translocation pathway in Escherichia coli. Ize, B., Gérard, F., Zhang, M., Chanal, A., Voulhoux, R., Palmer, T., Filloux, A., Wu, L.F. J. Mol. Biol. (2002) [Pubmed]

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