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Gene Review:

eptC - LPS heptose I phosphoethanolamine transferase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3946, JW3927, cptA, yijP

Wang, Y. et al., Huang, S.H. et al.

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Disease relevance of yijP

Sequence analysis indicated that the E. coli K1 yijP gene likely encodes a 66 [1].
This is the first demonstration that the yijP gene locus plays a role in the pathogenesis of E. coli K1 meningitis [1].

High impact information on yijP

The gene locus yijP contributes to Escherichia coli K1 invasion of brain microvascular endothelial cells [1].
Deletion and complementation experiments indicated that the yijP gene was involved in E. coli K1 invasion of BMEC, i.e., the invasive ability of E. coli K1 was significantly reduced after yijP was deleted and was restored by complementation with a plasmid containing the yijP open reading frame [1].
Nucleotide sequence revealed a near identity to that of a hypothetical yijP gene (also called f577) in the E. coli K-12 genome [1].
Genes contributing to invasion of brain microvascular endothelial cells include E. coli K1 genes ompA, ibeA, ibeB, and yijP [2].

References

The gene locus yijP contributes to Escherichia coli K1 invasion of brain microvascular endothelial cells. Wang, Y., Huang, S.H., Wass, C.A., Stins, M.F., Kim, K.S. Infect. Immun. (1999) [Pubmed]
Bacterial penetration across the blood-brain barrier during the development of neonatal meningitis. Huang, S.H., Stins, M.F., Kim, K.S. Microbes Infect. (2000) [Pubmed]

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