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Gene Review

hupA  -  HU, DNA-binding transcriptional regulator,...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3992, JW3964
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Disease relevance of hupA


High impact information on hupA

  • Surprisingly the introduction of a multi-copy plasmid carrying either the hupB or hupA gene into a wild-type E. coli strain, results in the overproduction of one of the HU subunits and repression of the synthesis of the other without changing the overall concentration of HU, also renders the cells mucoid [2].
  • Upon introduction of an HU-overproducing plasmid carrying either the hupB or the hupA gene into the wild-type and hup single deletion mutants, the intracellular levels of mRNA from the chromosomal hup genes are reduced [3].
  • The molecular mechanism of autoregulation of expression of the hupA gene in Escherichia coli was examined [4].

Biological context of hupA

  • Both hupB and hupA genes possess a DNA sequence with a rho-independent transcriptional terminator in their respective regions downstream from the coding regions [3].


  1. Cloning and sequencing of the hemE gene encoding uroporphyrinogen III decarboxylase (UPD) from Escherichia coli K-12. Nishimura, K., Nakayashiki, T., Inokuchi, H. Gene (1993) [Pubmed]
  2. An imbalance of HU synthesis induces mucoidy in Escherichia coli. Painbéni, E., Mouray, E., Gottesman, S., Rouvière-Yaniv, J. J. Mol. Biol. (1993) [Pubmed]
  3. Promoters and autogenous control of the Escherichia coli hupA and hupB genes. Kohno, K., Wada, M., Kano, Y., Imamoto, F. J. Mol. Biol. (1990) [Pubmed]
  4. Autoregulation of transcription of the hupA gene in Escherichia coli: evidence for steric hindrance of the functional promoter domains induced by HU. Kohno, K., Yasuzawa, K., Hirose, M., Kano, Y., Goshima, N., Tanaka, H., Imamoto, F. J. Biochem. (1994) [Pubmed]
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