Disease relevance of hupA

• This hemE was located at 90.3 min near the hupA gene on the linkage map of the E. coli chromosome [1].

High impact information on hupA

• Surprisingly the introduction of a multi-copy plasmid carrying either the hupB or hupA gene into a wild-type E. coli strain, results in the overproduction of one of the HU subunits and repression of the synthesis of the other without changing the overall concentration of HU, also renders the cells mucoid [2].
• Upon introduction of an HU-overproducing plasmid carrying either the hupB or the hupA gene into the wild-type and hup single deletion mutants, the intracellular levels of mRNA from the chromosomal hup genes are reduced [3].
• The molecular mechanism of autoregulation of expression of the hupA gene in Escherichia coli was examined [4].

Biological context of hupA

• Both hupB and hupA genes possess a DNA sequence with a rho-independent transcriptional terminator in their respective regions downstream from the coding regions [3].

References