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Gene Review:

nrdG - anaerobic ribonucleotide reductase...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4232, JW4196, yjgE

Garriga, X. et al., Torrents, E. et al.

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Disease relevance of nrdG

Lactococcus lactis contains an operon with the genes (nrdD and nrdG) for a class III ribonucleotide reductase [1].
nrdD and nrdG genes are essential for strict anaerobic growth of Escherichia coli [2].

Biological context of nrdG

We now show that knock-out mutants of either nrdD or nrdG cannot grow during strict anaerobiosis, achieved by inclusion of sodium sulfide in the medium [2].

References

The anaerobic (class III) ribonucleotide reductase from Lactococcus lactis. Catalytic properties and allosteric regulation of the pure enzyme system. Torrents, E., Buist, G., Liu, A., Eliasson, R., Kok, J., Gibert, I., Gräslund, A., Reichard, P. J. Biol. Chem. (2000) [Pubmed]
nrdD and nrdG genes are essential for strict anaerobic growth of Escherichia coli. Garriga, X., Eliasson, R., Torrents, E., Jordan, A., Barbé, J., Gibert, I., Reichard, P. Biochem. Biophys. Res. Commun. (1996) [Pubmed]

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