Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

nrdD - anaerobic ribonucleoside-triphosphate...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4233, JW4197

Garriga, X. et al., Sun, X. et al., Torrents, E. et al., Boston, T. et al.

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Disease relevance of nrdD

nrdD and nrdG genes are essential for strict anaerobic growth of Escherichia coli [1].
Lactococcus lactis contains an operon with the genes (nrdD and nrdG) for a class III ribonucleotide reductase [2].

High impact information on nrdD

A possible glycine radical in anaerobic ribonucleotide reductase from Escherichia coli: nucleotide sequence of the cloned nrdD gene [3].
The nrdD transcript start site was mapped to a position immediately downstream of two FNR binding sites [4].

Biological context of nrdD

We now show that knock-out mutants of either nrdD or nrdG cannot grow during strict anaerobiosis, achieved by inclusion of sodium sulfide in the medium [1].

References

nrdD and nrdG genes are essential for strict anaerobic growth of Escherichia coli. Garriga, X., Eliasson, R., Torrents, E., Jordan, A., Barbé, J., Gibert, I., Reichard, P. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
The anaerobic (class III) ribonucleotide reductase from Lactococcus lactis. Catalytic properties and allosteric regulation of the pure enzyme system. Torrents, E., Buist, G., Liu, A., Eliasson, R., Kok, J., Gibert, I., Gräslund, A., Reichard, P. J. Biol. Chem. (2000) [Pubmed]
A possible glycine radical in anaerobic ribonucleotide reductase from Escherichia coli: nucleotide sequence of the cloned nrdD gene. Sun, X., Harder, J., Krook, M., Jörnvall, H., Sjöberg, B.M., Reichard, P. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
FNR-mediated oxygen-responsive regulation of the nrdDG operon of Escherichia coli. Boston, T., Atlung, T. J. Bacteriol. (2003) [Pubmed]

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