Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

folE - GTP cyclohydrolase I

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2146, JW2140

El Yacoubi, B. et al., Schoedon, G. et al.

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Disease relevance of folE

GTP cyclohydrolase I (GCYH-I) is the first enzyme of the de novo tetrahydrofolate biosynthetic pathway present in bacteria, fungi, and plants, and encoded in Escherichia coli by the folE gene [1].

High impact information on folE

It is also the first enzyme of the biopterin (BH4) pathway in Homo sapiens, where it is encoded by a homologous folE gene [1].
In the presence of 1 mM EDTA and Mg2+, GTP-cyclohydrolase-I activity was strongly inhibited by chelate complexes [2].
GTP-cyclohydrolase-I activity was modulated in Vmax by K+, divalent cations, UTP and tetrahydrobiopterin [2].

References

Discovery of a new prokaryotic type I GTP cyclohydrolase family. El Yacoubi, B., Bonnett, S., Anderson, J.N., Swairjo, M.A., Iwata-Reuyl, D., de Cr??cy-Lagard, V. J. Biol. Chem. (2006) [Pubmed]
Allosteric characteristics of GTP cyclohydrolase I from Escherichia coli. Schoedon, G., Redweik, U., Frank, G., Cotton, R.G., Blau, N. Eur. J. Biochem. (1992) [Pubmed]

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