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Gene Review

folE  -  GTP cyclohydrolase I

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2146, JW2140
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Disease relevance of folE

  • GTP cyclohydrolase I (GCYH-I) is the first enzyme of the de novo tetrahydrofolate biosynthetic pathway present in bacteria, fungi, and plants, and encoded in Escherichia coli by the folE gene [1].

High impact information on folE


  1. Discovery of a new prokaryotic type I GTP cyclohydrolase family. El Yacoubi, B., Bonnett, S., Anderson, J.N., Swairjo, M.A., Iwata-Reuyl, D., de Cr??cy-Lagard, V. J. Biol. Chem. (2006) [Pubmed]
  2. Allosteric characteristics of GTP cyclohydrolase I from Escherichia coli. Schoedon, G., Redweik, U., Frank, G., Cotton, R.G., Blau, N. Eur. J. Biochem. (1992) [Pubmed]
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