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Chemical Compound Review

CTK2F6471     2-[2-(carboxylatomethyl...

Synonyms: STL089893, LS-190255, AKOS005655332, AC1L1MF5, 67840-47-5, ...
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Disease relevance of Edathamil

 

Psychiatry related information on Edathamil

  • Here, we report that, following treatment with EDTA, Puralpha was released from polyribosomes in mRNA/protein complexes (mRNPs), which also contained mStaufen, Fragile X Mental Retardation Protein (FMRP), myosin Va, and other proteins with unknown functions [6].
  • Also, the REM sleep deprivation induced increase in the enzyme activity was observed in lysed preparations and in the presence of EDTA only [7].
  • Use of EDTA to remove endogenous zinc appears to offer a mechanism for study of the effects of short-term zinc supplementation at critical periods in the pregnant zinc-deficient rat [8].
  • A low response time (<2 min) and a rapid recovery of response by EDTA seem the most interesting characteristics of the proposed biosensor at the present stage of development, along with the well known easy preparation of this kind of biosensors [9].
  • Whole blood in EDTA and unstimulated saliva samples were collected from 37 HIV(+) patients, of whom 20 had a history of intravenous drug abuse (IVDA) [10].
 

High impact information on Edathamil

  • The 100 kd protein also bound to native fibronectin receptor, and this binding could be reversed with EDTA [11].
  • This interaction is inhibited by anti-PADGEM antibodies, PADGEM, and EDTA; anti-GPIIb-IIIa, anti-thrombospondin, anti-GPIV, and thrombospondin produce no effect [12].
  • The mean (+/- SE) glomerular filtration rate, as measured by the clearance of 51Cr bound to EDTA, fell from 0.25 +/- 0.03 to 0.10 +/- 0.05 ml per second (P less than 0.01) in the group on the regular diet, whereas it fell from 0.23 +/- 0.04 to 0.20 +/- 0.05 ml per second (P not significant) in the group on the protein-restricted diet [13].
  • During development of Dictyostelium discoideum, a surface glycoprotein of Mr 80,000 (gp80) is known to mediate EDTA-resistant cell-cell adhesion via homophilic interaction [14].
  • However, treatment of the cytoskeletal fraction with EDTA or low levels of ribonuclease resulted in polysome degradation but no release [15].
 

Chemical compound and disease context of Edathamil

 

Biological context of Edathamil

  • Platelet aggregation was associated with adsorption of multimers of factor VIII/von Willebrand factor onto the platelets and was inhibited by EDTA [21].
  • This protein has been implicated in the EDTA-stable (Ca2(+)-independent) type of cell adhesion of aggregating cells [22].
  • Thus the ratio of protoporphyrin IX accumulation from ALA in cultures treated with CaMg EDTA compared with controls treated with ALA alone was greatest in normal cells, least in EPP cells, and intermediate in the heterozygote cells [23].
  • Neither EDTA, phenylmethylsulfonylfluoride, nor epsilon-amino-N-caproic acid prevented platelet-initiated formation of C5-9, suggesting that the reaction may involve mechanisms of complement activation not previously described [24].
  • After 1-2 h, the majority of the bound immune complexes were not released into the serum during blood clotting at either 37 degrees C or room temperature, but there was a considerably greater release of the immune complexes into the plasma of blood that was anticoagulated with EDTA [25].
 

Anatomical context of Edathamil

 

Associations of Edathamil with other chemical compounds

  • Conversion was less than 10% of normal when MPO-deficient PMNs were employed; formation by normal PMNs was inhibited by the peroxidase inhibitors, azide, and cyanide, and a model system consisting of MPO, H2O2, chloride (or bromide) and EDTA was found which shared many of the properties of the predominant PMN system [31].
  • We found that antisera to H-2.7 immunoprecipitated C4 and no other protein from mouse EDTA-plasma [32].
  • Addition of 1 mM Ca2+ to RPMI medium increased the binding of TSP to suspended U937 cells more than eightfold; the increase was blocked by EDTA but not by heparin [33].
  • Cytoplasmic extracts of CML leukocytes prepared with ice-cold 0.34-M sucrose solutions containing Mg2+-ATP, dithiothreitol, and EDTA at pH 7.0 underwent rapid gelation when warmed to 25 degrees C. Initially, the gel could be liquified by cooling to ice-bath temperature [34].
  • The consumption occurred in the absence of detectable anti-heart mitochondria autoantibody, was demonstrated to be calcium dependent, and was inhibited by either 0.01 M EDTA or ethylene glycol bis(bets-aminoethyl ether) N,N,N',N',-tetraacetic acid (EDTA) [35].
 

Gene context of Edathamil

  • The MMP inhibitors, EDTA and 1,10-phenanthroline, as well as recombinant TIMP-1, reduced these activities which colocalized with regions of increased immunoreactive MMP expression, i.e., the shoulders, core, and microvasculature of the plaques [36].
  • Immunoprecipitates of human C4 from EDTA-plasma were incubated with [14C]methylamine and analyzed by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis and fluorography [37].
  • Incubation of these two preparations resulted in a Mg-ATP-dependent inactivation of NR that was reversed with EDTA [38].
  • The catalytic properties of the Arg-35 mutant were changed so that PC activation by the mutant no longer required Ca2+ in the presence of TM, but, instead, it was accelerated by EDTA [39].
  • The TC-B12 binding sites in the proximal tubule epithelium colocalized with megalin as shown by ligand binding to cryosections of rat kidney cortex, and the binding was inhibited by anti-megalin polyclonal antibody, EDTA, and RAP [40].
 

Analytical, diagnostic and therapeutic context of Edathamil

  • The ligation reaction occurs rapidly on removal of Mg2+ by EDTA [41].
  • Immunoprecipitation experiments showed the GR antigen to be 110-120 kD Mr. The binding of soluble GR antigen was inhibited by EDTA and O-sialoglycoprotease, but not neuraminidase treatment of the target cells [42].
  • It was suggested that the C-C36 antigens responsible for tumor-rejection activity against the same tumor cells had a molecular weight range of approximately 150,000 to 250,000 (fraction II) in the presence of 5 mM EDTA and had been eluted into unbound fractions to lens culinaris lectin on affinity chromatography [43].
  • In the radioimmunoassay, antibody-containing plasma (1:100) is incubated with 0.2 pmoles of [3H]serotonin, EDTA, and either serotonin standards or unknown samples (0.1 ml) [44].
  • This 19S complex is of extraordinary stability: dissociated by 0.5 M KCl or EDTA from the (still repressed) core globin mRNP, it can be purified on gradients containing 1% Sarkosyl, and resists (unfixed) caesium sulphate-dimethylsulphoxide density centrifugation [45].

References

  1. Inefficacy of EDTA chelation therapy for coronary atherosclerosis. McGillem, M.J., Mancini, G.B. N. Engl. J. Med. (1988) [Pubmed]
  2. Chelation therapy for ischemic heart disease: a randomized controlled trial. Knudtson, M.L., Wyse, D.G., Galbraith, P.D., Brant, R., Hildebrand, K., Paterson, D., Richardson, D., Burkart, C., Burgess, E. JAMA (2002) [Pubmed]
  3. Immunogenicity of polysaccharides from type III, group B Streptococcus. Baker, C.J., Edwards, M.S., Kasper, D.L. J. Clin. Invest. (1978) [Pubmed]
  4. Characterization of human maligant melanoma cell lines. I. Morphology and growth characteristics in culture. Liao, S.K., Dent, P.B., McCulloch, P.B. J. Natl. Cancer Inst. (1975) [Pubmed]
  5. Characterization of antigens from nontypable Haemophilus influenzae recognized by human bactericidal antibodies. Role of Haemophilus outer membrane proteins. Gnehm, H.E., Pelton, S.I., Gulati, S., Rice, P.A. J. Clin. Invest. (1985) [Pubmed]
  6. Identification of mRNA/protein (mRNP) complexes containing Puralpha, mStaufen, fragile X protein, and myosin Va and their association with rough endoplasmic reticulum equipped with a kinesin motor. Ohashi, S., Koike, K., Omori, A., Ichinose, S., Ohara, S., Kobayashi, S., Sato, T.A., Anzai, K. J. Biol. Chem. (2002) [Pubmed]
  7. Comparison of Na-K ATPase activity in rat brain synaptosome under various conditions. Anupama Adya, H.V., Mallick, B.N. Neurochem. Int. (1998) [Pubmed]
  8. Use of EDTA to produce zinc deficiency in the pregnant rat. Apgar, J. J. Nutr. (1977) [Pubmed]
  9. Heavy metal determination by biosensors based on enzyme immobilised by electropolymerisation. Malitesta, C., Guascito, M.R. Biosensors & bioelectronics. (2005) [Pubmed]
  10. Enhanced secretory leukocyte protease inhibitor in human immunodeficiency virus type 1-infected patients. Baqui, A.A., Meiller, T.F., Falkler, W.A. Clin. Diagn. Lab. Immunol. (1999) [Pubmed]
  11. Fibulin, a novel protein that interacts with the fibronectin receptor beta subunit cytoplasmic domain. Argraves, W.S., Dickerson, K., Burgess, W.H., Ruoslahti, E. Cell (1989) [Pubmed]
  12. PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes. Larsen, E., Celi, A., Gilbert, G.E., Furie, B.C., Erban, J.K., Bonfanti, R., Wagner, D.D., Furie, B. Cell (1989) [Pubmed]
  13. The effect of protein restriction on the progression of renal insufficiency. Ihle, B.U., Becker, G.J., Whitworth, J.A., Charlwood, R.A., Kincaid-Smith, P.S. N. Engl. J. Med. (1989) [Pubmed]
  14. Identification of an octapeptide involved in homophilic interaction of the cell adhesion molecule gp80 of dictyostelium discoideum. Kamboj, R.K., Gariepy, J., Siu, C.H. Cell (1989) [Pubmed]
  15. Translational initiation factor and ribosome association with the cytoskeletal framework fraction from HeLa cells. Howe, J.G., Hershey, J.W. Cell (1984) [Pubmed]
  16. Increased angiotensin-converting enzyme in peripheral blood monocytes from patients with sarcoidosis. Okabe, T., Yamagata, K., Fujisawa, M., Watanabe, J., Takaku, F., Lanzillo, J.J., Fanburg, B.L. J. Clin. Invest. (1985) [Pubmed]
  17. Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Amici, A., Levine, R.L., Tsai, L., Stadtman, E.R. J. Biol. Chem. (1989) [Pubmed]
  18. Complete structural determination of lipopolysaccharide obtained from deep rough mutant of Escherichia coli. Purification by high performance liquid chromatography and direct analysis by plasma desorption mass spectrometry. Qureshi, N., Takayama, K., Mascagni, P., Honovich, J., Wong, R., Cotter, R.J. J. Biol. Chem. (1988) [Pubmed]
  19. Expression of the germ cell alkaline phosphatase gene in human choriocarcinoma cells. Watanabe, S., Watanabe, T., Li, W.B., Soong, B.W., Chou, J.Y. J. Biol. Chem. (1989) [Pubmed]
  20. Massive cerebral calcifications associated with increased renal phosphate reabsorption. Weisinger, J.R., Mogollón, A., Lander, R., Bellorin-Font, E., Riera, R., Abadí, I., Paz-Martínez, V. Arch. Intern. Med. (1986) [Pubmed]
  21. Platelet aggregation induced by 1-desamino-8-D-arginine vasopressin (DDAVP) in Type IIB von Willebrand's disease. Holmberg, L., Nilsson, I.M., Borge, L., Gunnarsson, M., Sjörin, E. N. Engl. J. Med. (1983) [Pubmed]
  22. Selective elimination of the contact site A protein of Dictyostelium discoideum by gene disruption. Harloff, C., Gerisch, G., Noegel, A.A. Genes Dev. (1989) [Pubmed]
  23. Accumulation of protoporphyrin IX from delta-aminolevulinic acid in bovine skin fibroblasts with hereditary erythropoietic protoporphyria. A gene-dosage effect. Sassa, S., Schwartz, S., Ruth, G. J. Exp. Med. (1981) [Pubmed]
  24. Human platelet-initiated formation and uptake of the C5-9 complex of human complement. Zimmerman, T.S., Kolb, W.P. J. Clin. Invest. (1976) [Pubmed]
  25. Dynamics of interaction between complement-fixing antibody/dsDNA immune complexes and erythrocytes. In vitro studies and potential general applications to clinical immune complex testing. Taylor, R.P., Horgan, C., Hooper, M., Burge, J. J. Clin. Invest. (1985) [Pubmed]
  26. Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Fleischer, T.C., Weaver, C.M., McAfee, K.J., Jennings, J.L., Link, A.J. Genes Dev. (2006) [Pubmed]
  27. The absence of H-2 antigens from mouse pancreatic beta-cells demonstrated by immunoferritin labeling. Parr, E.L. J. Exp. Med. (1979) [Pubmed]
  28. Arachidonic acid metabolism by human monocytes. Studies with platelet-depleted cultures. Pawlowski, N.A., Kaplan, G., Hamill, A.L., Cohn, Z.A., Scott, W.A. J. Exp. Med. (1983) [Pubmed]
  29. Isolation and characterization of the cytoplasmic and outer membranes of the Legionnaires' disease bacterium (Legionella pneumophila). Gabay, J.E., Horwitz, M.A. J. Exp. Med. (1985) [Pubmed]
  30. Origin, Kinetics, and characteristics of pulmonary macrophages in the normal steady state. van oud Alblas, A.B., van Furth, R. J. Exp. Med. (1979) [Pubmed]
  31. Ethylene formation by polymorphonuclear leukocytes. Role of myeloperoxidase. Klebanoff, S.J., Rosen, H. J. Exp. Med. (1978) [Pubmed]
  32. The murine H-2.7 specificity is an antigenic determinant of C4d, a fragment of the fourth component of the complement system. Ferreira, A., David, C.S., Nussenzweig, V. J. Exp. Med. (1980) [Pubmed]
  33. Ca2(+)-sensitive binding of thrombospondin to U937 cells is due to the formation of calcium precipitate in the binding medium. Sun, X., Mosher, D.F. J. Clin. Invest. (1991) [Pubmed]
  34. Interactions of actin, myosin, and an actin-binding protein of chronic myelogenous leukemia leukocytes. Boxer, L.A., Stossel, T.P. J. Clin. Invest. (1976) [Pubmed]
  35. Consumption of classical complement components by heart subcellular membranes in vitro and in patients after acute myocardial infarction. Pinckard, R.N., Olson, M.S., Giclas, P.C., Terry, R., Boyer, J.T., O'Rourke, R.A. J. Clin. Invest. (1975) [Pubmed]
  36. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. Galis, Z.S., Sukhova, G.K., Lark, M.W., Libby, P. J. Clin. Invest. (1994) [Pubmed]
  37. Identification and structural characterization of two incompletely processed forms of the fourth component of human complement. Chan, A.C., Atkinson, J.P. J. Clin. Invest. (1983) [Pubmed]
  38. Identification in vitro of a post-translational regulatory site in the hinge 1 region of Arabidopsis nitrate reductase. Su, W., Huber, S.C., Crawford, N.M. Plant Cell (1996) [Pubmed]
  39. Thrombomodulin allosterically modulates the activity of the anticoagulant thrombin. Rezaie, A.R., Yang, L. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  40. Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis. Moestrup, S.K., Birn, H., Fischer, P.B., Petersen, C.M., Verroust, P.J., Sim, R.B., Christensen, E.I., Nexø, E. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  41. Reversible cleavage and ligation of hepatitis delta virus RNA. Wu, H.N., Lai, M.M. Science (1989) [Pubmed]
  42. Characterization of an adhesion molecule that mediates leukocyte rolling on 24 h cytokine- or lipopolysaccharide-stimulated bovine endothelial cells under flow conditions. Jutila, M.A., Wilson, E., Kurk, S. J. Exp. Med. (1997) [Pubmed]
  43. Partial characterization of n-butanol-solubilized rejection-type antigens of syngeneic murine colon tumors. Sato, N., Kikuchi, K. J. Natl. Cancer Inst. (1985) [Pubmed]
  44. Validation and application of a radioimmunoassay for serotonin. Kellum, J.M., Jaffe, B.M. Gastroenterology (1976) [Pubmed]
  45. The prosome: an ubiquitous morphologically distinct RNP particle associated with repressed mRNPs and containing specific ScRNA and a characteristic set of proteins. Schmid, H.P., Akhayat, O., Martins De Sa, C., Puvion, F., Koehler, K., Scherrer, K. EMBO J. (1984) [Pubmed]
 
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