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Chemical Compound Review

Phenoptin     2-amino-6-(1,2- dihydroxypropyl)-5,6,7,8...

Synonyms: Dapropterin, Kuvan, Sapropterin, BPH4, CHEMBL1201774, ...
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Disease relevance of tetra-hydro-biopterin


Psychiatry related information on tetra-hydro-biopterin


High impact information on tetra-hydro-biopterin


Chemical compound and disease context of tetra-hydro-biopterin


Biological context of tetra-hydro-biopterin


Anatomical context of tetra-hydro-biopterin


Associations of tetra-hydro-biopterin with other chemical compounds


Gene context of tetra-hydro-biopterin


Analytical, diagnostic and therapeutic context of tetra-hydro-biopterin


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  2. Tetrahydrobiopterin restores endothelial function in hypercholesterolemia. Stroes, E., Kastelein, J., Cosentino, F., Erkelens, W., Wever, R., Koomans, H., Lüscher, T., Rabelink, T. J. Clin. Invest. (1997) [Pubmed]
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  15. Hyperphenylalaninemia due to a deficiency of biopterin. A variant form of phenylketonuria. Kaufman, S., Berlow, S., Summer, G.K., Milstien, S., Schulman, J.D., Orloff, S., Spielberg, S., Pueschel, S. N. Engl. J. Med. (1978) [Pubmed]
  16. The eNOS cofactor tetrahydrobiopterin improves endothelial dysfunction in livers of rats with CCl4 cirrhosis. Matei, V., Rodríguez-Vilarrupla, A., Deulofeu, R., Colomer, D., Fernández, M., Bosch, J., Garcia-Pagán, J.C. Hepatology (2006) [Pubmed]
  17. Sepiapterin attenuates 1-methyl-4-phenylpyridinium-induced apoptosis in neuroblastoma cells transfected with neuronal NOS: role of tetrahydrobiopterin, nitric oxide, and proteasome activation. Shang, T., Kotamraju, S., Zhao, H., Kalivendi, S.V., Hillard, C.J., Kalyanaraman, B. Free Radic. Biol. Med. (2005) [Pubmed]
  18. Biopterin-dependent hyperphenylalaninemia due to deficiency of 6-pyruvoyl tetrahydropterin synthase. al Aqeel, A., Ozand, P.T., Gascon, G., Nester, M., al Nasser, M., Brismar, J., Blau, N., Hughes, H., Subramanyan, S.B., Reynolds, C.T. Neurology (1991) [Pubmed]
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  20. Bacterial translocation in cirrhotic rats stimulates eNOS-derived NO production and impairs mesenteric vascular contractility. Wiest, R., Das, S., Cadelina, G., Garcia-Tsao, G., Milstien, S., Groszmann, R.J. J. Clin. Invest. (1999) [Pubmed]
  21. Inducible nitric oxide synthase: role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction. Ghosh, D.K., Crane, B.R., Ghosh, S., Wolan, D., Gachhui, R., Crooks, C., Presta, A., Tainer, J.A., Getzoff, E.D., Stuehr, D.J. EMBO J. (1999) [Pubmed]
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  23. Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation. Fischmann, T.O., Hruza, A., Niu, X.D., Fossetta, J.D., Lunn, C.A., Dolphin, E., Prongay, A.J., Reichert, P., Lundell, D.J., Narula, S.K., Weber, P.C. Nat. Struct. Biol. (1999) [Pubmed]
  24. Peripherally administered reduced pterins do enter the brain. Kapatos, G., Kaufman, S. Science (1981) [Pubmed]
  25. Tetrahydrobiopterin in striatum: localization in dopamine nerve terminals and role in catecholamine synthesis. Levine, R.A., Miller, L.P., Lovenberg, W. Science (1981) [Pubmed]
  26. Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts. Werner-Felmayer, G., Werner, E.R., Fuchs, D., Hausen, A., Reibnegger, G., Wachter, H. J. Exp. Med. (1990) [Pubmed]
  27. Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity. Rosenkranz-Weiss, P., Sessa, W.C., Milstien, S., Kaufman, S., Watson, C.A., Pober, J.S. J. Clin. Invest. (1994) [Pubmed]
  28. Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. Landmesser, U., Dikalov, S., Price, S.R., McCann, L., Fukai, T., Holland, S.M., Mitch, W.E., Harrison, D.G. J. Clin. Invest. (2003) [Pubmed]
  29. Effect of aluminium on in-vitro tetrahydrobiopterin synthesis in brain preparations. Cowburn, J.D., Blair, J.A. Lancet (1987) [Pubmed]
  30. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia. Verhaar, M.C., Wever, R.M., Kastelein, J.J., van Dam, T., Koomans, H.A., Rabelink, T.J. Circulation (1998) [Pubmed]
  31. Characterization of key residues in the subdomain encoded by exons 8 and 9 of human inducible nitric oxide synthase: a critical role for Asp-280 in substrate binding and subunit interactions. Ghosh, D.K., Rashid, M.B., Crane, B., Taskar, V., Mast, M., Misukonis, M.A., Weinberg, J.B., Eissa, N.T. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  32. PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major. Bello, A.R., Nare, B., Freedman, D., Hardy, L., Beverley, S.M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  33. 1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide. Shang, T., Kotamraju, S., Kalivendi, S.V., Hillard, C.J., Kalyanaraman, B. J. Biol. Chem. (2004) [Pubmed]
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  35. Striatal biopterin and tyrosine hydroxylase protein reduction in dopa-responsive dystonia. Furukawa, Y., Nygaard, T.G., Gütlich, M., Rajput, A.H., Pifl, C., DiStefano, L., Chang, L.J., Price, K., Shimadzu, M., Hornykiewicz, O., Haycock, J.W., Kish, S.J. Neurology (1999) [Pubmed]
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