Chemical Compound Review:
boranuide boron(-1) tetrahydride anion
Synonyms:
CHEBI:30157, BH4(-), AC1L1EO1, [BH4](-), tetrahydroborate(1-), ...
- Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression. Alp, N.J., Mussa, S., Khoo, J., Cai, S., Guzik, T., Jefferson, A., Goh, N., Rockett, K.A., Channon, K.M. J. Clin. Invest. (2003)
- Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load. Takimoto, E., Champion, H.C., Li, M., Ren, S., Rodriguez, E.R., Tavazzi, B., Lazzarino, G., Paolocci, N., Gabrielson, K.L., Wang, Y., Kass, D.A. J. Clin. Invest. (2005)
- Restoration of endothelium-dependent vasodilation after reperfusion injury by tetrahydrobiopterin. Tiefenbacher, C.P., Chilian, W.M., Mitchell, M., DeFily, D.V. Circulation (1996)
- Hyperphenylalaninemia due to defects in tetrahydrobiopterin metabolism: molecular characterization of mutations in 6-pyruvoyl-tetrahydropterin synthase. Thöny, B., Leimbacher, W., Blau, N., Harvie, A., Heizmann, C.W. Am. J. Hum. Genet. (1994)
- BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death. Shimizu, S., Konishi, A., Kodama, T., Tsujimoto, Y. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Effects of electroconvulsive shock on tetrahydrobiopterin and GTP-cyclohydrolase activity in the brain and adrenal gland of the rat. Hossain, M.A., Masserano, J.M., Weiner, N. J. Neurochem. (1992)
- Tetrahydrobiopterin, a cofactor for NOS, improves endothelial dysfunction during chronic alcohol consumption. Sun, H., Patel, K.P., Mayhan, W.G. Am. J. Physiol. Heart Circ. Physiol. (2001)
- CSF dopamine, serotonin, and biopterin metabolites in patients with restless legs syndrome. Earley, C.J., Hyland, K., Allen, R.P. Mov. Disord. (2001)
- Evaluation of tetrahydrobiopterin (BH4) as a potential therapeutic agent to treat erectile dysfunction. Sommer, F., Klotz, T., Steinritz, D., Bloch, W. Asian J. Androl. (2006)
- Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2. Shibasaki, F., Kondo, E., Akagi, T., McKeon, F. Nature (1997)
- Role of Nr13 in regulation of programmed cell death in the bursa of Fabricius. Lee, R.M., Gillet, G., Burnside, J., Thomas, S.J., Neiman, P. Genes Dev. (1999)
- The eNOS cofactor tetrahydrobiopterin improves endothelial dysfunction in livers of rats with CCl4 cirrhosis. Matei, V., Rodríguez-Vilarrupla, A., Deulofeu, R., Colomer, D., Fernández, M., Bosch, J., Garcia-Pagán, J.C. Hepatology (2006)
- Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta. Shinozaki, K., Kashiwagi, A., Nishio, Y., Okamura, T., Yoshida, Y., Masada, M., Toda, N., Kikkawa, R. Diabetes (1999)
- Tetrahydrobiopterin restores endothelial function in long-term smokers. Ueda, S., Matsuoka, H., Miyazaki, H., Usui, M., Okuda, S., Imaizumi, T. J. Am. Coll. Cardiol. (2000)
- Sepiapterin attenuates 1-methyl-4-phenylpyridinium-induced apoptosis in neuroblastoma cells transfected with neuronal NOS: role of tetrahydrobiopterin, nitric oxide, and proteasome activation. Shang, T., Kotamraju, S., Zhao, H., Kalivendi, S.V., Hillard, C.J., Kalyanaraman, B. Free Radic. Biol. Med. (2005)
- The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4. Huang, D.C., Adams, J.M., Cory, S. EMBO J. (1998)
- Bcl-2 Phosphorylation by p38 MAPK: identification of target sites and biologic consequences. De Chiara, G., Marcocci, M.E., Torcia, M., Lucibello, M., Rosini, P., Bonini, P., Higashimoto, Y., Damonte, G., Armirotti, A., Amodei, S., Palamara, A.T., Russo, T., Garaci, E., Cozzolino, F. J. Biol. Chem. (2006)
- The hydroxylation of phenylalanine and tyrosine by tyrosine hydroxylase from cultured pheochromocytoma cells. Ribeiro, P., Pigeon, D., Kaufman, S. J. Biol. Chem. (1991)
- Subunit interactions of endothelial nitric-oxide synthase. Comparisons to the neuronal and inducible nitric-oxide synthase isoforms. Venema, R.C., Ju, H., Zou, R., Ryan, J.W., Venema, V.J. J. Biol. Chem. (1997)
- Coordinate regulation of tetrahydrobiopterin turnover and phenylalanine hydroxylase activity in rat liver cells. Mitnaul, L.J., Shiman, R. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Double transduction with GTP cyclohydrolase I and tyrosine hydroxylase is necessary for spontaneous synthesis of L-DOPA by primary fibroblasts. Bencsics, C., Wachtel, S.R., Milstien, S., Hatakeyama, K., Becker, J.B., Kang, U.J. J. Neurosci. (1996)
- Glucocorticoids regulate inducible nitric oxide synthase by inhibiting tetrahydrobiopterin synthesis and L-arginine transport. Simmons, W.W., Ungureanu-Longrois, D., Smith, G.K., Smith, T.W., Kelly, R.A. J. Biol. Chem. (1996)
- The hph-1 mouse: a model for dominantly inherited GTP-cyclohydrolase deficiency. Hyland, K., Gunasekara, R.S., Munk-Martin, T.L., Arnold, L.A., Engle, T. Ann. Neurol. (2003)
- Tetrahydrobiopterin, a critical factor in the production and role of nitric oxide in mast cells. Gilchrist, M., Hesslinger, C., Befus, A.D. J. Biol. Chem. (2003)
- Discovery of a new prokaryotic type I GTP cyclohydrolase family. El Yacoubi, B., Bonnett, S., Anderson, J.N., Swairjo, M.A., Iwata-Reuyl, D., de Cr??cy-Lagard, V. J. Biol. Chem. (2006)
- Boo, a novel negative regulator of cell death, interacts with Apaf-1. Song, Q., Kuang, Y., Dixit, V.M., Vincenz, C. EMBO J. (1999)
- Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process. Xia, Y., Tsai, A.L., Berka, V., Zweier, J.L. J. Biol. Chem. (1998)
- BCL-2 and BCL-XL restrict lineage choice during hematopoietic differentiation. Haughn, L., Hawley, R.G., Morrison, D.K., von Boehmer, H., Hockenbery, D.M. J. Biol. Chem. (2003)
- A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosynthesis. Martínez, A., Knappskog, P.M., Haavik, J. Current medicinal chemistry. (2001)
- Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2. Grandgirard, D., Studer, E., Monney, L., Belser, T., Fellay, I., Borner, C., Michel, M.R. EMBO J. (1998)
- Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease. Mandel, R.J., Rendahl, K.G., Spratt, S.K., Snyder, R.O., Cohen, L.K., Leff, S.E. J. Neurosci. (1998)
- Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor. Tayeh, M.A., Marletta, M.A. J. Biol. Chem. (1989)