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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TP53I11  -  tumor protein p53 inducible protein 11

Homo sapiens

Synonyms: PIG11, Tumor protein p53-inducible protein 11, p53-induced gene 11 protein
 
 
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Disease relevance of TP53I11

 

High impact information on TP53I11

  • The above results suggest that overexpression of PIG11 could induce cell apoptosis in the low levels and enhanced the apoptotic effects of arsenic trioxide [2].
  • Recent data demonstrated that PIG11 was up-regulated markedly in arsenic trioxide induced apoptosis by DDRT-PCR, suggesting a new class of p53 target genes that sensitize cells to the effects of chemotherapeutic agents [2].
  • In this study, through the construction of a recombinant GFP-PIG11 expression vector and transfection of HEK293 cells with GFP or GFP-PIG11, the role of PIG11 in apoptosis was analyzed [2].
  • These results suggest that PIG11, as a downstream target of p53, is involved in apoptosis of MGC-803 cells [1].
  • In this study, we found PIG11, a p53-induced gene, was upregulated markedly by As2O3 using the technique of differential display reverse transcriptase PCR (DDRT-PCR) [1].
 

Biological context of TP53I11

  • In addition, we showed that intracellular content of reactive oxygen species (ROS) was 9.66+/-0.52 in GFP-PIG11 transfection, higher than 5.21+/-0.08 in GFP only and 5.99+/-0.45 in vehicle control (P<0.01) [2].
  • Addition of anti-PIG11 phosphorothioated oligonucleotide (5'-GGC CGC CAT CTT CTC CTC-3') before As2O3 treatment, abolished the transient increase in PIG11 gene expression [1].
 

Associations of TP53I11 with chemical compounds

  • At 24 h after 1 microM of arsenic trioxide treatment, apoptotic cells exhibited a significant increase in the expression of GFP-PIG11 (36.67%+/-2.78), in contrast, 10.50%+/-2.03 only GFP and 5.25%+/-0.96 vehicle control (P<0.01) [2].

References

  1. P53-induced gene 11 (PIG11) involved in arsenic trioxide-induced apoptosis in human gastric cancer MGC-803 cells. Liang, X.Q., Cao, E.H., Zhang, Y., Qin, J.F. Oncol. Rep. (2003) [Pubmed]
  2. A P53 target gene, PIG11, contributes to chemosensitivity of cells to arsenic trioxide. Liang, X.Q., Cao, E.H., Zhang, Y., Qin, J.F. FEBS Lett. (2004) [Pubmed]
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