Gene Review:
sll1076 - ATPase P
Synechocystis sp. PCC 6803
This record was discontinued.
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Disease relevance of ziaA
- ORF slr0798, now designated ziaA, from Synechocystis PCC 6803 encodes a polypeptide with sequence features of heavy metal transporting P-type ATPases [1].
- Increased Zn2+ tolerance and reduced 65Zn accumulation was observed in Synechococcus PCC 7942, strain R2-PIM8(smt), containing ziaA and upstream regulatory sequences, compared with control cells [1].
High impact information on ziaA
- Nucleotide sequences upstream of ziaA, fused to a promoterless lacZ gene, conferred Zn2+-dependent beta-galactosidase activity when introduced into R2-PIM8(smt) [1].
- Reporter gene constructs lacking ziaR conferred elevated Zn2+-independent expression from the ziaA operator-promoter in R2-PIM8(smt) [1].
References
- An SmtB-like repressor from Synechocystis PCC 6803 regulates a zinc exporter. Thelwell, C., Robinson, N.J., Turner-Cavet, J.S. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
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