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Gene Review

pgk  -  phosphoglycerate kinase

Escherichia coli O157:H7 str. EDL933

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Disease relevance of pgk


High impact information on pgk

  • The genes encoding these enzymes (gap and pgk, respectively) form a bicistronic operon, and some form of regulation is required to provide this differential expression [1].
  • Three plasmid vectors have been created using either the glucoamylase A (amyA), pyruvate decarboxylase (pdcA), or phosphoglycerate kinase (pgk1) promoters to drive expression of heterologous proteins [2].


  1. Segmental message stabilization as a mechanism for differential expression from the Zymomonas mobilis gap operon. Eddy, C.K., Keshav, K.F., An, H., Utt, E.A., Mejia, J.P., Ingram, L.O. J. Bacteriol. (1991) [Pubmed]
  2. Plasmids for expression of heterologous proteins in Rhizopus oryzae. Mertens, J.A., Skory, C.D., Ibrahim, A.S. Arch. Microbiol. (2006) [Pubmed]
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