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Gene Review

alkA  -  3-methyladenine DNA glycosylase

Escherichia coli O157:H7 str. EDL933

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High impact information on alkA

  • When the ada gene with the Ala69 mutation was introduced into the cell, there was little induction of expression of either the ada or the alkA genes, even after treatment with an alkylating agent, in agreement with the data obtained from studies in vitro [1].
  • The actions of mutant Ada proteins on the ada and alkA promoters in vivo were investigated using an artificially composed gene expression system [1].
  • Replacement of the cysteine residue at position 69, but not at position 321, abolished the ability of Ada protein to promote transcription of both ada and alkA genes in vitro [1].


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