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Chemical Compound Review

Zanosar     1-methyl-1-nitroso-3- [(2S,3R,4R,5S,6R)-2,4...

Synonyms: STRZ, streptozocin, streptozosin, Streptozocine, Estreptozocina, ...
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Disease relevance of STREPTOZOTOCIN


Psychiatry related information on STREPTOZOTOCIN

  • Alzheimer's disease cells exhibit defective repair of alkylating agent-induced DNA damage [6].
  • The ability of three serotonin-uptake blockers to reverse the performance deficit in learning induced by previous uncontrollable stress (learned-helplessness paradigm) was investigated in streptozocin-induced diabetic rats [7].
  • Prolonged food deprivation (FD) and streptozocin-induced diabetes (STZ diabetes) in the rat result in abolition of GH secretory episodes [8].
  • In the present study a murine mAb (5G12-4, Ab3) that bears the 16/6 Id and binds to DNA was produced and was found to bind rabbit anti-16/6 Id sera and murine anti-16/6 Id mAb similarly to the human mAb 16/6 Id (Ab1) [9].
  • Motor activity was assayed by sequentially adsorbing either kinesin or dynein to acid-washed coverslips, treating with an alkylating agent or control solution, adding microtubules and ATP, and finally imaging and quantifying the binding and gliding of microtubules using video-enhanced differential interference contrast (VE-DIC) microscopy [10].

High impact information on STREPTOZOTOCIN


Chemical compound and disease context of STREPTOZOTOCIN


Biological context of STREPTOZOTOCIN


Anatomical context of STREPTOZOTOCIN

  • We report here the identification of a human B-cell nuclear factor (IgNF-A) that binds to DNA sequences in the upstream regions of both the mouse heavy and kappa light-chain gene promoters and also to the mouse heavy-chain gene enhancer [26].
  • Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin [27].
  • Because Ets2 is localized in the nucleus of macrophages and binds to DNA in vitro, the kinetics of its expression suggest a role for Ets2 in the transduction within the nucleus of specific signals received at the cell membrane and involved in securing the survival and/or the development of functional competence of these cells [28].
  • Recombinant PEA3 binds to DNA with the same sequence specificity as that endogenous to FM3A cells and activates transcription through the PEA3 motif in HeLa cells [29].
  • We also found that this phenomenon, which we refer to as "acquired multicellular resistance," is associated with an increase in intercellular adhesion or compaction of the alkylating agent-resistant cell lines grown as aggregates in three-dimensional culture [30].

Associations of STREPTOZOTOCIN with other chemical compounds


Gene context of STREPTOZOTOCIN


Analytical, diagnostic and therapeutic context of STREPTOZOTOCIN


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