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Gene Review

rpsL  -  30S ribosomal protein S12

Escherichia coli O157:H7 str. EDL933

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Disease relevance of rpsL

  • Mutations conferring resistance to low levels of kanamycin in Escherichia coli have been mapped at 3 locations: the unc locus (min. 83), a locus we have designated kanA (MIN. 72), close to strA (rpsL), and a locus at min [1].

High impact information on rpsL

  • The unc and ecfB mutations are associated with defects in energy metabolism, while mutations at kanA may be in the gene coding for ribosomal protein S12 (rpsL) [1].
  • In this system, any form of inactivation mutation in the rpsL gene can be positively selected since it makes the E. coli cells resistant to streptomycin [2].


  1. Mutations determining generalized resistance to aminoglycoside antibiotics in Escherichia coli. Thorbjarnardóttir, S.H., Magnúsdóttir, R.A., Eggertsson, G. Mol. Gen. Genet. (1978) [Pubmed]
  2. A New System for Detecting Mutations in Arabidopsis thaliana and the Mutational Spectra Resulting from Ethylmethanesulfonate Treatment. Yoshihara, R., Nakane, C., Takimoto, K. J. Radiat. Res. (2006) [Pubmed]
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