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Gene Review:

fimA - major type 1 subunit fimbrin (pilin)

Escherichia coli O157:H7 str. EDL933

Tinker, J.K. et al., Blumer, C. et al.

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Disease relevance of fimA

Extensive in vitro DNA binding assays using extracts from E. coli that overexpress FimY, as well as partially purified FimY, were unable to identify a specific interaction between FimY and the fimA or fimY promoter [1].

High impact information on fimA

Studies using the fimY-lacZ construct reveal that expression of this gene varies with environmental conditions in a manner similar to fimA expression [1].
In vitro, LrhA bound to the promoter regions of the two fim recombinases (FimB and FimE) that catalyse the inversion of the fimA promoter, and to the invertible element itself [2].

References

Characterization of FimY as a coactivator of type 1 fimbrial expression in Salmonella enterica serovar Typhimurium. Tinker, J.K., Clegg, S. Infect. Immun. (2000) [Pubmed]
Regulation of type 1 fimbriae synthesis and biofilm formation by the transcriptional regulator LrhA of Escherichia coli. Blumer, C., Kleefeld, A., Lehnen, D., Heintz, M., Dobrindt, U., Nagy, G., Michaelis, K., Emödy, L., Polen, T., Rachel, R., Wendisch, V.F., Unden, G. Microbiology (Reading, Engl.) (2005) [Pubmed]

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