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Gene Review:

gyrB - DNA gyrase subunit B

Escherichia coli O157:H7 str. EDL933

Grossman, T.H. et al., Niwa, H. et al., Toriello, N.M. et al.

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Disease relevance of gyrB

Multiplexed differential gene expression analysis is demonstrated on mdh and gyrB E. coli transcripts [1].
In this study, the quinolone resistance-determining region (QRDR) in gyrA and gyrB of in vitro fluoroquinolone-resistant Rhodococcus equi mutants was sequenced [2].

High impact information on gyrB

Furthermore, gyrB and parE double mutations increased the MICs of VRT-125853 and VRT-752586 significantly, providing evidence of dual targeting [3].
Novobiocin resistance-conferring mutations in S. aureus, H. influenzae, and S. pneumoniae were found in gyrB, and these mutants showed little or no cross-resistance to VRT-125853 or VRT-752586 and vice versa [3].

References

Multichannel reverse transcription-polymerase chain reaction microdevice for rapid gene expression and biomarker analysis. Toriello, N.M., Liu, C.N., Mathies, R.A. Anal. Chem. (2006) [Pubmed]
A nucleotide mutation associated with fluoroquinolone resistance observed in gyrA of in vitro obtained Rhodococcus equi mutants. Niwa, H., Hobo, S., Anzai, T. Vet. Microbiol. (2006) [Pubmed]
Dual Targeting of GyrB and ParE by a Novel Aminobenzimidazole Class of Antibacterial Compounds. Grossman, T.H., Bartels, D.J., Mullin, S., Gross, C.H., Parsons, J.D., Liao, Y., Grillot, A.L., Stamos, D., Olson, E.R., Charifson, P.S., Mani, N. Antimicrob. Agents Chemother. (2007) [Pubmed]

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