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Gene Review

RAB36  -  RAB36, member RAS oncogene family

Homo sapiens

Synonyms: Ras-related protein Rab-36
 
 
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Disease relevance of RAB36

 

High impact information on RAB36

 

Biological context of RAB36

  • Experiments to induce over-expression of Rab36 by transfection to an MRT cell line similarly failed to justify designation of this gene as a tumor suppressor that would contribute to tumorigenesis by a loss-of-function mechanism [2].

References

  1. Isolation of genes from the rhabdoid tumor deletion region in chromosome band 22q11.2. Zhou, J., Fogelgren, B., Wang, Z., Roe, B.A., Biegel, J.A. Gene (2000) [Pubmed]
  2. Cloning and characterization of a novel Rab-family gene, Rab36, within the region at 22q11.2 that is homozygously deleted in malignant rhabdoid tumors. Mori, T., Fukuda, Y., Kuroda, H., Matsumura, T., Ota, S., Sugimoto, T., Nakamura, Y., Inazawa, J. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
 
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