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Gene Review:

RAB36 - RAB36, member RAS oncogene family

Homo sapiens

Synonyms: Ras-related protein Rab-36

Zhou, J. et al., Mori, T. et al.

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Disease relevance of RAB36

Further studies of RTDR1 and RAB36 are required to determine whether their absence contributes to the progression of rhabdoid tumors [1].

High impact information on RAB36

A series of primary rhabdoid tumors with chromosome 22q11 deletions were screened for mutations in the coding sequences of RTDR1, GNAZ and RAB36, but did not demonstrate any disease-specific alterations [1].
Sequencing of Rab36 cDNAs from three cell lines that retained at least one allele of this gene revealed no nonsense or frameshift mutations [2].
As it showed a high degree of sequence homology to genes of the Rab family, we designated it Rab36 [2].

Biological context of RAB36

Experiments to induce over-expression of Rab36 by transfection to an MRT cell line similarly failed to justify designation of this gene as a tumor suppressor that would contribute to tumorigenesis by a loss-of-function mechanism [2].

References

Isolation of genes from the rhabdoid tumor deletion region in chromosome band 22q11.2. Zhou, J., Fogelgren, B., Wang, Z., Roe, B.A., Biegel, J.A. Gene (2000) [Pubmed]
Cloning and characterization of a novel Rab-family gene, Rab36, within the region at 22q11.2 that is homozygously deleted in malignant rhabdoid tumors. Mori, T., Fukuda, Y., Kuroda, H., Matsumura, T., Ota, S., Sugimoto, T., Nakamura, Y., Inazawa, J. Biochem. Biophys. Res. Commun. (1999) [Pubmed]

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RAB36	Bos taurus
RAB36	Canis lupus familiaris
rab36	Danio rerio
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RAB36	Gallus gallus
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rab36	Xenopus (Silurana) tropicalis

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