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Gene Review:

pgsA - phosphatidylglycerophosphate synthetase

Escherichia coli O157:H7 str. EDL933

Nagahama, H. et al., Jiang, H. et al., Suzuki, M. et al.

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Disease relevance of pgsA

RcsA-dependent and -independent growth defects caused by the activated Rcs phosphorelay system in the Escherichia coli pgsA null mutant [1].
Metabolically-engineered Escherichia coli strains were developed by cloning poly-gamma-glutamic acid (gamma-PGA) biosynthesis genes, consisting of pgsB, pgsC and pgsA, from Bacillus subtilis The metabolic and regulatory pathways of gamma-PGA biosynthesis in E. coli were analyzed by DNA microarray [2].

High impact information on pgsA

We suggest that this anomalous anchoring largely explains a major portion of the nonviable phenotypes of pgsA null mutants [3].
Here we show that Lpp expressed from a plasmid causes cell lysis in a pgsA lpp double mutant [3].
In the Escherichia coli pgsA null mutant, which lacks the major acidic phospholipids, the Rcs phosphorelay signal transduction system is activated, causing thermosensitive growth [1].

References

RcsA-dependent and -independent growth defects caused by the activated Rcs phosphorelay system in the Escherichia coli pgsA null mutant. Nagahama, H., Sakamoto, Y., Matsumoto, K., Hara, H. J. Gen. Appl. Microbiol. (2006) [Pubmed]
Optimal Production of Poly-gamma-glutamic Acid by Metabolically Engineered Escherichia coli. Jiang, H., Shang, L., Yoon, S.H., Lee, S.Y., Yu, Z. Biotechnol. Lett. (2006) [Pubmed]
Envelope disorder of Escherichia coli cells lacking phosphatidylglycerol. Suzuki, M., Hara, H., Matsumoto, K. J. Bacteriol. (2002) [Pubmed]

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