The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

GUCA1C  -  guanylate cyclase activator 1C

Homo sapiens

Synonyms: GCAP 3, GCAP3, Guanylate cyclase activator 1C, Guanylyl cyclase-activating protein 3
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on GUCA1C

  • Here we present evidence of the presence of a new photoreceptor-specific GCAP, termed GCAP3, which is closely related to GCAP1 [1].
  • While the GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on chromosome 6p in human, the GCAP3 gene is located on 3q13.1, suggesting an ancestral gene duplication/translocation event [1].
  • GCAP3 contains two domains with the EF-hand motifs arranged in a tandem array similar to GCAP2 and members of the recoverin subfamily of Ca2+-binding proteins [2].
  • GCAP3 is an EF-hand Ca2+-binding protein with Ca2+ bound to EF2, 3 and 4, while Ca2+ binding to EF-hand 1 is disabled [2].
 

Other interactions of GUCA1C

  • The intron/exon arrangement of the GCAP3 gene is identical to that of the other GCAP genes [1].
 

Analytical, diagnostic and therapeutic context of GUCA1C

  • GCAP3 is encoded by a distinct gene present in other mammalian species but could not be detected by genomic Southern blotting in rodents, amphibians, and lower vertebrates [1].

References

  1. Molecular characterization of a third member of the guanylyl cyclase-activating protein subfamily. Haeseleer, F., Sokal, I., Li, N., Pettenati, M., Rao, N., Bronson, D., Wechter, R., Baehr, W., Palczewski, K. J. Biol. Chem. (1999) [Pubmed]
  2. The crystal structure of GCAP3 suggests molecular mechanism of GCAP-linked cone dystrophies. Stephen, R., Palczewski, K., Sousa, M.C. J. Mol. Biol. (2006) [Pubmed]
 
WikiGenes - Universities