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Gene Review

GUCA1C  -  guanylate cyclase activator 1C

Homo sapiens

Synonyms: GCAP 3, GCAP3, Guanylate cyclase activator 1C, Guanylyl cyclase-activating protein 3
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High impact information on GUCA1C

  • Here we present evidence of the presence of a new photoreceptor-specific GCAP, termed GCAP3, which is closely related to GCAP1 [1].
  • While the GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on chromosome 6p in human, the GCAP3 gene is located on 3q13.1, suggesting an ancestral gene duplication/translocation event [1].
  • GCAP3 contains two domains with the EF-hand motifs arranged in a tandem array similar to GCAP2 and members of the recoverin subfamily of Ca2+-binding proteins [2].
  • GCAP3 is an EF-hand Ca2+-binding protein with Ca2+ bound to EF2, 3 and 4, while Ca2+ binding to EF-hand 1 is disabled [2].

Other interactions of GUCA1C

  • The intron/exon arrangement of the GCAP3 gene is identical to that of the other GCAP genes [1].

Analytical, diagnostic and therapeutic context of GUCA1C

  • GCAP3 is encoded by a distinct gene present in other mammalian species but could not be detected by genomic Southern blotting in rodents, amphibians, and lower vertebrates [1].


  1. Molecular characterization of a third member of the guanylyl cyclase-activating protein subfamily. Haeseleer, F., Sokal, I., Li, N., Pettenati, M., Rao, N., Bronson, D., Wechter, R., Baehr, W., Palczewski, K. J. Biol. Chem. (1999) [Pubmed]
  2. The crystal structure of GCAP3 suggests molecular mechanism of GCAP-linked cone dystrophies. Stephen, R., Palczewski, K., Sousa, M.C. J. Mol. Biol. (2006) [Pubmed]
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