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Gene Review

RCVRN  -  recoverin

Homo sapiens

Synonyms: Cancer-associated retinopathy protein, Protein CAR, RCV1, Recoverin
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Disease relevance of RCVRN


High impact information on RCVRN

  • Cancer-associated retinopathy (CAR syndrome) with antibodies reacting with retinal, optic-nerve, and cancer cells [6].
  • Recoverin has a relative molecular mass of 23,000 (M[r] 23K), and contains an amino-terminal myristoyl group (or related acyl group) and four EF hands [7].
  • One such protein is recoverin, a calcium sensor in retinal rod cells, which controls the lifetime of photoexcited rhodopsin by inhibiting rhodopsin kinase [7].
  • The conservation of the myristoyl binding site and two swivels in recoverin homologues from yeast to humans indicates that calcium-myristoyl switches are ancient devices for controlling calcium-sensitive processes [7].
  • The binding of two Ca2+ ions to recoverin leads to its translocation from the cytosol to the disc membrane [7].

Chemical compound and disease context of RCVRN


Biological context of RCVRN


Anatomical context of RCVRN


Associations of RCVRN with chemical compounds


Physical interactions of RCVRN


Regulatory relationships of RCVRN


Other interactions of RCVRN

  • Immunocytochemistry revealed that immunoreactivities toward Rec within the cancer cells were almost identical to those toward GRKs and caveolin-1 [1].
  • GCAP3 contains two domains with the EF-hand motifs arranged in a tandem array similar to GCAP2 and members of the recoverin subfamily of Ca2+-binding proteins [21].
  • This study was undertaken to develop the recoverin locus into a polymorphic marker for future linkage studies on retinitis pigmentosa families [10].
  • A homology model of CIB based upon calcineurin B and recoverin indicated a conserved hydrophobic pocket within the C-terminal EF-hand motifs of CIB as a potential integrin-binding site [22].
  • In peripheral retina at 15.4 weeks to 1 month after birth, displaced cones in the nerve fiber layer are positive for TULP1, recoverin, and blue cone opsin [23].

Analytical, diagnostic and therapeutic context of RCVRN


  1. Aberrantly expressed recoverin is functionally associated with G-protein-coupled receptor kinases in cancer cell lines. Miyagawa, Y., Ohguro, H., Odagiri, H., Maruyama, I., Maeda, T., Maeda, A., Sasaki, M., Nakazawa, M. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  2. A photoreceptor calcium binding protein is recognized by autoantibodies obtained from patients with cancer-associated retinopathy. Polans, A.S., Buczyłko, J., Crabb, J., Palczewski, K. J. Cell Biol. (1991) [Pubmed]
  3. The cancer-associated retinopathy antigen is a recoverin-like protein. Thirkill, C.E., Tait, R.C., Tyler, N.K., Roth, A.M., Keltner, J.L. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  4. Expression of a photoreceptor protein, recoverin, as a cancer-associated retinopathy autoantigen in human lung cancer cell lines. Matsubara, S., Yamaji, Y., Sato, M., Fujita, J., Takahara, J. Br. J. Cancer (1996) [Pubmed]
  5. Functional analysis of the human recoverin gene promoter. Wiechmann, A., Howard, E. Curr. Eye Res. (2003) [Pubmed]
  6. Cancer-associated retinopathy (CAR syndrome) with antibodies reacting with retinal, optic-nerve, and cancer cells. Thirkill, C.E., FitzGerald, P., Sergott, R.C., Roth, A.M., Tyler, N.K., Keltner, J.L. N. Engl. J. Med. (1989) [Pubmed]
  7. Molecular mechanics of calcium-myristoyl switches. Ames, J.B., Ishima, R., Tanaka, T., Gordon, J.I., Stryer, L., Ikura, M. Nature (1997) [Pubmed]
  8. Tamoxifen side effects, age-related macular degeneration (AMD) or cancer associated retinopathy (CAR)? Sadowski, B., Kriegbaum, C., Apfelstedt-Sylla, E. European journal of ophthalmology. (2001) [Pubmed]
  9. Structural Basis for Calcium-induced Inhibition of Rhodopsin Kinase by Recoverin. Ames, J.B., Levay, K., Wingard, J.N., Lusin, J.D., Slepak, V.Z. J. Biol. Chem. (2006) [Pubmed]
  10. Genetic and physical mapping of human recoverin: a gene expressed in retinal photoreceptors. Wiechmann, A.F., Akots, G., Hammarback, J.A., Pettenati, M.J., Rao, P.N., Bowden, D.W. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
  11. Recoverin as a cancer-retina antigen. Bazhin, A.V., Schadendorf, D., Philippov, P.P., Eichm??ller, S.B. Cancer Immunol. Immunother. (2007) [Pubmed]
  12. Ca2+-dependent conformational changes in the neuronal Ca2+-sensor recoverin probed by the fluorescent dye Alexa647. Gensch, T., Komolov, K.E., Senin, I.I., Philippov, P.P., Koch, K.W. Proteins (2007) [Pubmed]
  13. Recoverin, a photoreceptor-specific calcium-binding protein, is expressed by the tumor of a patient with cancer-associated retinopathy. Polans, A.S., Witkowska, D., Haley, T.L., Amundson, D., Baizer, L., Adamus, G. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  14. Autophosphorylation and ADP regulate the Ca2+-dependent interaction of recoverin with rhodopsin kinase. Satpaev, D.K., Chen, C.K., Scotti, A., Simon, M.I., Hurley, J.B., Slepak, V.Z. Biochemistry (1998) [Pubmed]
  15. Recoverin in pineal organs and retinae of various vertebrate species including man. Korf, H.W., White, B.H., Schaad, N.C., Klein, D.C. Brain Res. (1992) [Pubmed]
  16. Recoverin: a calcium sensitive activator of retinal rod guanylate cyclase. Dizhoor, A.M., Ray, S., Kumar, S., Niemi, G., Spencer, M., Brolley, D., Walsh, K.A., Philipov, P.P., Hurley, J.B., Stryer, L. Science (1991) [Pubmed]
  17. Recoverin: a potent uveitogen for the induction of photoreceptor degeneration in Lewis rats. Adamus, G., Ortega, H., Witkowska, D., Polans, A. Exp. Eye Res. (1994) [Pubmed]
  18. Regulation of G-protein-coupled receptor kinase subtypes by calcium sensor proteins. Iacovelli, L., Sallese, M., Mariggiò, S., de Blasi, A. FASEB J. (1999) [Pubmed]
  19. Mechanisms of photoreceptor cell death in cancer-associated retinopathy. Maeda, T., Maeda, A., Maruyama, I., Ogawa , K.I., Kuroki, Y., Sahara, H., Sato, N., Ohguro, H. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  20. Invasive thymoma with paraneoplastic retinopathy. Yamada, G., Ohguro, H., Aketa, K., Itoh, T., Shijubo, N., Takahashi, H., Fujiwara, O., Satoh, M., Ohtsuka, K., Abe, S. Hum. Pathol. (2003) [Pubmed]
  21. The crystal structure of GCAP3 suggests molecular mechanism of GCAP-linked cone dystrophies. Stephen, R., Palczewski, K., Sousa, M.C. J. Mol. Biol. (2006) [Pubmed]
  22. Molecular basis of CIB binding to the integrin alpha IIb cytoplasmic domain. Barry, W.T., Boudignon-Proudhon, C., Shock, D.D., McFadden, A., Weiss, J.M., Sondek, J., Parise, L.V. J. Biol. Chem. (2002) [Pubmed]
  23. Localization of tubby-like protein 1 in developing and adult human retinas. Milam, A.H., Hendrickson, A.E., Xiao, M., Smith, J.E., Possin, D.E., John, S.K., Nishina, P.M. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  24. Turned on by Ca2+! The physiology and pathology of Ca(2+)-binding proteins in the retina. Polans, A., Baehr, W., Palczewski, K. Trends Neurosci. (1996) [Pubmed]
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