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Gene Review

SEMA3E  -  sema domain, immunoglobulin domain (Ig),...

Homo sapiens

Synonyms: KIAA0331, M-SEMAH, M-SemaK, SEMAH, Semaphorin-3E, ...
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Disease relevance of SEMA3E

  • Now, besides providing evidence for the relevance of SEMA3E to human disease by showing that SEMA3E is frequently expressed in human cancer cell lines and solid tumors from breast cancer patients, we show biological activities of Sema3E, which support the implication of Sema3E in tumor progression and metastasis [1].

High impact information on SEMA3E


  1. Proteolytic processing converts the repelling signal Sema3E into an inducer of invasive growth and lung metastasis. Christensen, C., Ambartsumian, N., Gilestro, G., Thomsen, B., Comoglio, P., Tamagnone, L., Guldberg, P., Lukanidin, E. Cancer Res. (2005) [Pubmed]
  2. Class 3 semaphorin signaling: the end of a dogma. Potiron, V., Roche, J. Sci. STKE (2005) [Pubmed]
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