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Gene Review:

int - integrase

Listeria monocytogenes EGD-e

Domínguez-Bernal, G. et al., Emoto, M. et al.

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Disease relevance of int

The region between the core genome loci ysnB-tRNA(arg) and ydeI flanking LIPI-2 contained different gene complements in the different Listeria spp. and even serovars of L. monocytogenes, including remnants of the PSA bacteriophage int gene in serovar 4b, indicating it is a hot spot for horizontal genome diversification [1].

High impact information on int

In the liver, the major target organ of listeriosis, an unusual T lymphocyte population exists with the intriguing phenotype CD4+ NK1.1+ TCR alpha/beta intermediate (TCR alpha/beta int) [2].
Here we show that IL-4-producing CD4+ NK1.1+ TCR alpha/beta int liver lymphocytes are down-regulated early in listeriosis [2].

References

A spontaneous genomic deletion in Listeria ivanovii identifies LIPI-2, a species-specific pathogenicity island encoding sphingomyelinase and numerous internalins. Domínguez-Bernal, G., Müller-Altrock, S., González-Zorn, B., Scortti, M., Herrmann, P., Monzó, H.J., Lacharme, L., Kreft, J., Vázquez-Boland, J.A. Mol. Microbiol. (2006) [Pubmed]
Interleukin-4-producing CD4+ NK1.1+ TCR alpha/beta intermediate liver lymphocytes are down-regulated by Listeria monocytogenes. Emoto, M., Emoto, Y., Kaufmann, S.H. Eur. J. Immunol. (1995) [Pubmed]

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