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Gene Review:

fri - non-heme iron-binding ferritin

Listeria monocytogenes EGD-e

Olsen, K.N. et al., Dussurget, O. et al.

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Disease relevance of fri

In this study of the food-borne pathogen Listeria monocytogenes, the fri gene encoding a Dps homologue was deleted, and, compared to wild-type cells, it was found that the resulting mutant was less resistant to hydrogen peroxide, and demonstrated reduced survival following long-term (7-11 days) incubation in laboratory media [1].

High impact information on fri

Given the role of Fri in resistance to oxidative stress, and growth under iron-limiting conditions, the ability of the fri mutant to infect mice was examined [1].
In view of this, it is shown that fri gene expression is controlled by the hydrogen peroxide regulator PerR, as well as the general stress sigma factor sigmaB [1].
Together, our study demonstrates that fri has multiple roles that contribute to Listeria virulence [2].
The fri gene encoding the ferritin was deleted and the phenotype of the mutant was analyzed demonstrating that ferritin is necessary for optimal growth in minimal medium in both presence and absence of iron, as well as after cold- and heat-shock [2].

References

The Dps-like protein Fri of Listeria monocytogenes promotes stress tolerance and intracellular multiplication in macrophage-like cells. Olsen, K.N., Larsen, M.H., Gahan, C.G., Kallipolitis, B., Wolf, X.A., Rea, R., Hill, C., Ingmer, H. Microbiology (Reading, Engl.) (2005) [Pubmed]
Listeria monocytogenes ferritin protects against multiple stresses and is required for virulence. Dussurget, O., Dumas, E., Archambaud, C., Chafsey, I., Chambon, C., Hébraud, M., Cossart, P. FEMS Microbiol. Lett. (2005) [Pubmed]

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