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Gene Review

LPPR4  -  lipid phosphate phosphatase-related...

Homo sapiens

Synonyms: LPR4, PHP1, PRG-1, PRG1
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High impact information on LPPR4

  • PRG-1 is specifically expressed in neurons and is located in the membranes of outgrowing axons [1].
  • Expression analyses of the neurite growth-related proteins f-actin, neuronal class III beta-tubulin and plasticity-related gene-1, and stereological estimates of growth cone densities revealed a more vigorous regenerative response in the proximal nerve stump of blind SD/RCS rats compared with SD animals at 5-7 days after buccal nerve transection [2].
  • Plasticity-related serine proteases in the brain (review) [3].


  1. A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting. Bräuer, A.U., Savaskan, N.E., Kühn, H., Prehn, S., Ninnemann, O., Nitsch, R. Nat. Neurosci. (2003) [Pubmed]
  2. Improved outcome of facial nerve repair in rats is associated with enhanced regenerative response of motoneurons and augmented neocortical plasticity. Peeva, G.P., Angelova, S.K., Guntinas-Lichius, O., Streppel, M., Irintchev, A., Sch??tz, U., Popratiloff, A., Savaskan, N.E., Br??uer, A.U., Alvanou, A., Nitsch, R., Angelov, D.N. Eur. J. Neurosci. (2006) [Pubmed]
  3. Plasticity-related serine proteases in the brain (review). Yoshida, S., Shiosaka, S. Int. J. Mol. Med. (1999) [Pubmed]
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