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Gene Review

USP15  -  ubiquitin specific peptidase 15

Homo sapiens

Synonyms: Deubiquitinating enzyme 15, KIAA0529, UNPH-2, UNPH4, Ubiquitin carboxyl-terminal hydrolase 15, ...
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High impact information on USP15

  • It binds numerous proteins, including the Ub E3 ligases and the deubiquitinating enzyme Ubp12p, the S. pombe ortholog of human USP15 [1].
  • Mutation of a single conserved cysteine residue in the predicted Zn binding motif resulted in the loss of USP15 capability to degrade poly-Ub substrates, indicating that the Zn finger is essential for the cleavage of poly-Ub chains [1].


  1. The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1. Hetfeld, B.K., Helfrich, A., Kapelari, B., Scheel, H., Hofmann, K., Guterman, A., Glickman, M., Schade, R., Kloetzel, P.M., Dubiel, W. Curr. Biol. (2005) [Pubmed]
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