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Gene Review

Kcnc4  -  potassium voltage gated channel, Shaw...

Mus musculus

Synonyms: AI850292, KSHIIIC, Kcr2-4, Kv3.4, Potassium voltage-gated channel subfamily C member 4, ...
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Psychiatry related information on Kcnc4


High impact information on Kcnc4

  • MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis [2].
  • Kv3.3 K+ channels are believed to incorporate an NH2-terminal domain to produce an intermediate rate of inactivation relative to the fast inactivating K+ channels Kv3.4 and Kv1 [3].
  • Immunocytochemistry revealed the presence of Kv3.4 channels in delta-cells and TEA-resistant Kv4.3 channels in alpha-cells [4].
  • The corresponding mouse gene, Kcnc4, consists of five exons spanning a region of 20 kb [5].

Associations of Kcnc4 with chemical compounds

  • Light- and electron-microscopic immunohistochemistry revealed Kv3.3 and Kv3.4 subunits within all motor nerve terminals of muscles examined [transversus abdominus, lumbrical and flexor digitorum brevis (FDB)] [6].


  1. Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease. Angulo, E., Noé, V., Casadó, V., Mallol, J., Gomez-Isla, T., Lluis, C., Ferrer, I., Ciudad, C.J., Franco, R. J. Neurochem. (2004) [Pubmed]
  2. MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis. Abbott, G.W., Butler, M.H., Bendahhou, S., Dalakas, M.C., Ptacek, L.J., Goldstein, S.A. Cell (2001) [Pubmed]
  3. Inactivation of Kv3.3 potassium channels in heterologous expression systems. Fernandez, F.R., Morales, E., Rashid, A.J., Dunn, R.J., Turner, R.W. J. Biol. Chem. (2003) [Pubmed]
  4. Patch-clamp characterisation of somatostatin-secreting -cells in intact mouse pancreatic islets. Göpel, S.O., Kanno, T., Barg, S., Rorsman, P. J. Physiol. (Lond.) (2000) [Pubmed]
  5. The genomic basis of K(V)3.4 potassium channel mRNA diversity in mice. Vullhorst, D., Jockusch, H., Bartsch, J.W. Gene (2001) [Pubmed]
  6. Kv3 voltage-gated potassium channels regulate neurotransmitter release from mouse motor nerve terminals. Brooke, R.E., Moores, T.S., Morris, N.P., Parson, S.H., Deuchars, J. Eur. J. Neurosci. (2004) [Pubmed]
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