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MeSH Review

Somatostatin-Secreting Cells

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Disease relevance of Somatostatin-Secreting Cells


High impact information on Somatostatin-Secreting Cells

  • TLC1 RNA, which determines the sequence of telomeric DNA in vivo, was present in normal amounts in est1 delta cells [6].
  • A 3.7 kb mRNA coding for the G-CSF receptor could be detected in mouse myeloid leukemia NFS-60 and WEHI-3B D+ cells as well as in bone marrow cells [7].
  • Increased expression of Class I (HLA-A, B, and C) molecules was observed in the affected islet cells, and in damaged islets showing scant lymphocytic infiltration, some beta cells (still producing insulin), but not glucagon or somatostatin cells, were HLA-DR positive [8].
  • We propose that the early expression of Pax4 in a subset of endocrine progenitors is essential for the differentiation of the beta and delta cell lineages [9].
  • Small synthetic peptides that correspond to different portions of the 65-kilodalton mycobacterial heat shock protein (Hsp65) were used to identify a putative antigenic epitope for gamma delta cells [10].

Chemical compound and disease context of Somatostatin-Secreting Cells


Biological context of Somatostatin-Secreting Cells


Anatomical context of Somatostatin-Secreting Cells

  • LAK cells induced by IL-7, like those induced by IL-2, were phenotypically heterogeneous and included CD8+, CD56+, and gamma/delta+ cells [21].
  • Data now show that in both rats and humans this new molecular form is concentrated in the D cell of the gastrointestinal mucosa together with somatostatin-28(1-12) [22].
  • Adrenergic modulation of pancreatic A, B, and D cells alpha-Adrenergic suppression and beta-adrenergic stimulation of somatostatin secretion, alpha-adrenergic stimulation of glucagon secretion in the perfused dog pancreas [23].
  • Two populations of RA-treated FL cells could be identified: one with an intermediate RNA content (T-cells) similar to near-plateau-phase control cultures and the other with low RNA content (Q-cells) similar to that observed for DMSO-differentiated (D) cells [24].
  • Ultrastructural studies performed on pyloric D cells using the protein A-gold technique reveals that antrin is present in the same secretory granules as somatostatin-28(1-12) and detectable in one-third of all secretory granules [22].

Associations of Somatostatin-Secreting Cells with chemical compounds

  • A monoclonal antibody directed against TCR delta was produced that binds specifically to the surface of several TCR gamma delta cell lines and immunoprecipitates the TCR gamma delta as a heterodimer from Triton X-100 detergent lysates and also immunoprecipitates the TCR delta subunit alone after chain separation [25].
  • Functional studies revealed that, while both TCR-gamma/delta+ cell subsets showed CD3-mediated activation, only BB3+ (or Ti gamma A+) cells, but not delta TCS1+ cells, appeared to proliferate in response to PPD in PPD-reactive individuals [26].
  • Prosomatostatin-derived antrin is present in gastric D cells and in portal blood [22].
  • Despite the association of a normal quantity of intracellular cobalamin with methionine synthetase, the proportion of intracellular cobalamin which was methyl-B12 was below normal and in the range observed in cobalamin C and D cells [27].
  • GABA labeling was also observed in two other antral endocrine cell types, classified by morphological criteria as somatostatin producing D cells and serotonin producing ECn cells [28].

Gene context of Somatostatin-Secreting Cells

  • Our study indicates a requirement of Arx for alpha-cell fate acquisition and a repressive action on beta-and delta-cell destiny, which is exactly the opposite of the action of Pax4 in endocrine commitment [29].
  • This indicates that SDB25 function is confined to M/G1, and morphological analysis of sdb25 delta cells supports this conclusion [30].
  • A CCK-mediated stimulation of paracrine somatostatin secretion from antral and fundic D cells represents a candidate mechanism for the inhibition of the parietal and gastrin cell in humans [31].
  • Oxyntic D-cell density was the same in both mutant strains, but the D cells were more active in the gastrin KO than in the double-KO mice [32].
  • The D cell is activated by either gastrin or CCK and appears to be inhibited by acetylcholine and somatostatin [33].

Analytical, diagnostic and therapeutic context of Somatostatin-Secreting Cells


  1. Effect of Helicobacter pylori eradication on G-cell and D-cell density in children. Queiroz, D.M., Moura, S.B., Mendes, E.N., Rocha, G.A., Barbosa, A.J., de Carvalho, A.S. Lancet (1994) [Pubmed]
  2. A novel FK506- and rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus. Benton, B.M., Zang, J.H., Thorner, J. J. Cell Biol. (1994) [Pubmed]
  3. Hypertrophy and hyperplasia of somatostatin-containing D-cells in diabetes. Orci, L., Baetens, D., Rufener, C., Amherdt, M., Ravazzola, M., Studer, P., Malaisse-Lagae, F., Unger, R.H. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  4. Multiple sclerosis: limited diversity of the V delta 2-J delta 3 T-cell receptor in chronic active lesions. Battistini, L., Selmaj, K., Kowal, C., Ohmen, J., Modlin, R.L., Raine, C.S., Brosnan, C.F. Ann. Neurol. (1995) [Pubmed]
  5. Divergent stimulatory and inhibitory actions of carbamoylcholine on gastric D-cells. Chiba, T., Raffoul, K., Yamada, T. J. Biol. Chem. (1987) [Pubmed]
  6. An in vitro assay for Saccharomyces telomerase requires EST1. Lin, J.J., Zakian, V.A. Cell (1995) [Pubmed]
  7. Expression cloning of a receptor for murine granulocyte colony-stimulating factor. Fukunaga, R., Ishizaka-Ikeda, E., Seto, Y., Nagata, S. Cell (1990) [Pubmed]
  8. In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. Bottazzo, G.F., Dean, B.M., McNally, J.M., MacKay, E.H., Swift, P.G., Gamble, D.R. N. Engl. J. Med. (1985) [Pubmed]
  9. The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Sosa-Pineda, B., Chowdhury, K., Torres, M., Oliver, G., Gruss, P. Nature (1997) [Pubmed]
  10. Recognition of a peptide antigen by heat shock--reactive gamma delta T lymphocytes. Born, W., Hall, L., Dallas, A., Boymel, J., Shinnick, T., Young, D., Brennan, P., O'Brien, R. Science (1990) [Pubmed]
  11. HSV-1 glycoprotein I-reactive TCR gamma delta cells directly recognize the peptide backbone in a conformationally dependent manner. Sciammas, R., Bluestone, J.A. J. Immunol. (1998) [Pubmed]
  12. Inactivation of the Saccharomyces cerevisiae SKY1 gene induces a specific modification of the yeast anticancer drug sensitivity profile accompanied by a mutator phenotype. Schenk, P.W., Boersma, A.W., Brok, M., Burger, H., Stoter, G., Nooter, K. Mol. Pharmacol. (2002) [Pubmed]
  13. Repair of psoralen adducts in human DNA: differences among xeroderma pigmentosum complementation groups. Cleaver, J.E., Gruenert, D.C. J. Invest. Dermatol. (1984) [Pubmed]
  14. Hypergastrinemia in response to gastric inflammation suppresses somatostatin. Zavros, Y., Rieder, G., Ferguson, A., Samuelson, L.C., Merchant, J.L. Am. J. Physiol. Gastrointest. Liver Physiol. (2002) [Pubmed]
  15. The effect of tripotassium dicitrato bismuthate on the rat stomach. Waldum, H.L., Qvigstad, G., Mårvik, R., Brenna, E., Syversen, U., Sandvik, A.K. Aliment. Pharmacol. Ther. (1994) [Pubmed]
  16. Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. Otero, G., Fellows, J., Li, Y., de Bizemont, T., Dirac, A.M., Gustafsson, C.M., Erdjument-Bromage, H., Tempst, P., Svejstrup, J.Q. Mol. Cell (1999) [Pubmed]
  17. Defective development of gamma/delta T cells in interleukin 7 receptor-deficient mice is due to impaired expression of T cell receptor gamma genes. Kang, J., Coles, M., Raulet, D.H. J. Exp. Med. (1999) [Pubmed]
  18. PACAP type I receptor activation regulates ECL cells and gastric acid secretion. Zeng, N., Athmann, C., Kang, T., Lyu, R.M., Walsh, J.H., Ohning, G.V., Sachs, G., Pisegna, J.R. J. Clin. Invest. (1999) [Pubmed]
  19. Intraepithelial gamma delta T-cell-receptor lymphocytes and genetic susceptibility to coeliac disease. Holm, K., Mäki, M., Savilahti, E., Lipsanen, V., Laippala, P., Koskimies, S. Lancet (1992) [Pubmed]
  20. epsilon-COP is a structural component of coatomer that functions to stabilize alpha-COP. Duden, R., Kajikawa, L., Wuestehube, L., Schekman, R. EMBO J. (1998) [Pubmed]
  21. Interleukin 7 enhances cytolytic T lymphocyte generation and induces lymphokine-activated killer cells from human peripheral blood. Alderson, M.R., Sassenfeld, H.M., Widmer, M.B. J. Exp. Med. (1990) [Pubmed]
  22. Prosomatostatin-derived antrin is present in gastric D cells and in portal blood. Ravazzola, M., Benoit, R., Ling, N., Orci, L. J. Clin. Invest. (1989) [Pubmed]
  23. Adrenergic modulation of pancreatic A, B, and D cells alpha-Adrenergic suppression and beta-adrenergic stimulation of somatostatin secretion, alpha-adrenergic stimulation of glucagon secretion in the perfused dog pancreas. Samols, E., Weir, G.C. J. Clin. Invest. (1979) [Pubmed]
  24. Effects of retinoic acid versus dimethyl sulfoxide on Friend erythroleukemia cell growth. I. Cell proliferation, RNA content, and protein content. Traganos, F., Bueti, C., Darzynkiewicz, Z., Melamed, M.R. J. Natl. Cancer Inst. (1984) [Pubmed]
  25. Immunochemical proof that a novel rearranging gene encodes the T cell receptor delta subunit. Band, H., Hochstenbach, F., McLean, J., Hata, S., Krangel, M.S., Brenner, M.B. Science (1987) [Pubmed]
  26. Differential expression of CD45RO (UCHL1) and its functional relevance in two subpopulations of circulating TCR-gamma/delta+ lymphocytes. Miyawaki, T., Kasahara, Y., Taga, K., Yachie, A., Taniguchi, N. J. Exp. Med. (1990) [Pubmed]
  27. Altered vitamin B12 metabolism in fibroblasts from a patient with megaloblastic anemia and homocystinuria due to a new defect in methionine biosynthesis. Rosenblatt, D.S., Cooper, B.A., Pottier, A., Lue-Shing, H., Matiaszuk, N., Grauer, K. J. Clin. Invest. (1984) [Pubmed]
  28. Colocalization of gamma-aminobutyrate and gastrin in the rat antrum: an immunocytochemical and in situ hybridization study. Davanger, S., Hjelle, O.P., Babaie, E., Larsson, L.I., Hougaard, D., Storm-Mathisen, J., Ottersen, O.P. Gastroenterology (1994) [Pubmed]
  29. Opposing actions of Arx and Pax4 in endocrine pancreas development. Collombat, P., Mansouri, A., Hecksher-Sorensen, J., Serup, P., Krull, J., Gradwohl, G., Gruss, P. Genes Dev. (2003) [Pubmed]
  30. P40SDB25, a putative CDK inhibitor, has a role in the M/G1 transition in Saccharomyces cerevisiae. Donovan, J.D., Toyn, J.H., Johnson, A.L., Johnston, L.H. Genes Dev. (1994) [Pubmed]
  31. Cholecystokinin is a negative regulator of gastric acid secretion and postprandial release of gastrin in humans. Schmidt, W.E., Schenk, S., Nustede, R., Holst, J.J., Fölsch, U.R., Creutzfeldt, W. Gastroenterology (1994) [Pubmed]
  32. Altered control of gastric acid secretion in gastrin-cholecystokinin double mutant mice. Chen, D., Zhao, C.M., Håkanson, R., Samuelson, L.C., Rehfeld, J.F., Friis-Hansen, L. Gastroenterology (2004) [Pubmed]
  33. Physiology of isolated gastric endocrine cells. Sachs, G., Zeng, N., Prinz, C. Annu. Rev. Physiol. (1997) [Pubmed]
  34. Expression of the calcium-sensing receptor on human antral gastrin cells in culture. Ray, J.M., Squires, P.E., Curtis, S.B., Meloche, M.R., Buchan, A.M. J. Clin. Invest. (1997) [Pubmed]
  35. A temperature-sensitive NUP116 null mutant forms a nuclear envelope seal over the yeast nuclear pore complex thereby blocking nucleocytoplasmic traffic. Wente, S.R., Blobel, G. J. Cell Biol. (1993) [Pubmed]
  36. Treatment of Helicobacter gastritis with IL-4 requires somatostatin. Zavros, Y., Rathinavelu, S., Kao, J.Y., Todisco, A., Del Valle, J., Weinstock, J.V., Low, M.J., Merchant, J.L. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
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