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PTBP3  -  polypyrimidine tract binding protein 3

Homo sapiens

Synonyms: DKFZp781I1117, Polypyrimidine tract-binding protein 3, ROD1, Regulator of differentiation 1, Rod1
 
 
 
 
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High impact information on ROD1

  • Like nrd1(+) for fission yeast differentiation, overexpressed ROD1 effectively blocks both 12-O-tetradecanoyl phorbol-13-acetate-induced megakaryocytic and sodium butyrate-induced erythroid differentiation of the K562 human leukemia cells without affecting their proliferative ability [1].
  • By using the phenotypic suppression of the S. pombe temperature-sensitive pat1 mutant that commits lethal haploid meiosis at the restrictive temperature, we have cloned ROD1, a functional homologue of nrd1(+), from rat and human cDNA libraries [1].

References

  1. Isolation of a mammalian homologue of a fission yeast differentiation regulator. Yamamoto, H., Tsukahara, K., Kanaoka, Y., Jinno, S., Okayama, H. Mol. Cell. Biol. (1999) [Pubmed]
 
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