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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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MeSH Review: 

Leukemia, Mast-Cell

 
 
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High impact information on Leukemia, Mast-Cell

  • Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin [1].
  • Here we report on the stimulatory nature of gp49A by analyzing biochemical characteristics of chimeric molecules consisting of an ectodomain of Fc receptor and a C-terminal half of gp49A, namely the pretransmembrane, transmembrane, and cytoplasmic portions, expressed on the rat basophilic leukemia mast cell line [2].
  • We found that in the rat basophilic leukemia mast cell line, addition of wheat germ agglutinin, a lectin that binds to the Fc epsilon RI alpha subunit, caused a precipitous decline in the lateral diffusional and electrokinetic mobilities of the Fc epsilon RI [3].
  • RESULTS: RANTES and CCR1 were expressed on T cells and mast cells in OLP, while OLP lesional T cell supernatants stimulated CCR1 mRNA expression in a human leukemia mast cell line (HMC-1) [4].

References

  1. Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin. Nakajima, H., Park, H.L., Henkart, P.A. J. Exp. Med. (1995) [Pubmed]
  2. Stimulatory function of gp49A, a murine Ig-like receptor, in rat basophilic leukemia cells. Lee, K.H., Ono, M., Inui, M., Yuasa, T., Takai, T. J. Immunol. (2000) [Pubmed]
  3. Immobilization of Fc epsilon receptors by wheat germ agglutinin. Receptor dynamics in IgE-mediated signal transduction. McCloskey, M.A. J. Immunol. (1993) [Pubmed]
  4. Expression of RANTES and CCR1 in oral lichen planus and association with mast cell migration. Zhao, Z.Z., Sugerman, P.B., Walsh, L.J., Savage, N.W. J. Oral Pathol. Med. (2002) [Pubmed]
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