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Gene Review

Fcer1a  -  Fc fragment of IgE, high affinity I,...

Rattus norvegicus

Synonyms: Fc-epsilon RI-alpha, FcERI, Fce1a, High affinity immunoglobulin epsilon receptor subunit alpha, IgE Fc receptor subunit alpha, ...
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Disease relevance of Fcer1a


High impact information on Fcer1a

  • In order to identify the smallest Fc fragment capable of binding to the Fc epsilon RI alpha with high affinity, various regions of the IgE-Fc molecule were expressed in COS cells and investigated for their ability to bind Fc epsilon RI alpha [3].
  • These human Fc epsilon RI alpha-transfected cell lines have been characterized with respect to the association of the human alpha subunit with endogenous rat beta and gamma subunits and the ability of aggregated Fc epsilon RI alpha subunits to mediate a variety of biochemical events [4].
  • In contrast to MCD peptide, [Ala12]MCD showed a 50% inhibition of IgE binding to the Fc epsilon RI alpha mast cell receptor by using rat basophilic leukemia (RBL-2H3) mast cells and fluorescence polarization [5].

Anatomical context of Fcer1a

  • We synthesized various analogues of indolyl, naphthyl and phenylethyl substituted halopyridyl, thiazolyl and benzothiazolyl thioureas and examined their in vitro effects on the high affinity IgE receptor/FcERI-mediated mast cell leukotriene release [6].

Analytical, diagnostic and therapeutic context of Fcer1a


  1. Immobilization of Fc epsilon receptors by wheat germ agglutinin. Receptor dynamics in IgE-mediated signal transduction. McCloskey, M.A. J. Immunol. (1993) [Pubmed]
  2. Tissue-specific expression in mouse P815 mastocytoma cells of the cloned rat alpha-subunit gene of the high-affinity receptor for immunoglobulin E. Witthuhn, B.A., Faust, C. Immunol. Lett. (1995) [Pubmed]
  3. Purification and characterization of human recombinant IgE-Fc fragments that bind to the human high affinity IgE receptor. Basu, M., Hakimi, J., Dharm, E., Kondas, J.A., Tsien, W.H., Pilson, R.S., Lin, P., Gilfillan, A., Haring, P., Braswell, E.H. J. Biol. Chem. (1993) [Pubmed]
  4. Conservation of signal transduction mechanisms via the human Fc epsilon RI alpha after transfection into a rat mast cell line, RBL 2H3. Gilfillan, A.M., Kado-Fong, H., Wiggan, G.A., Hakimi, J., Kent, U., Kochan, J.P. J. Immunol. (1992) [Pubmed]
  5. [Ala12]MCD peptide: a lead peptide to inhibitors of immunoglobulin E binding to mast cell receptors. Buku, A., Condie, B.A., Price, J.A., Mezei, M. J. Pept. Res. (2005) [Pubmed]
  6. Inhibition of mast cell leukotriene release by thiourea derivatives. Venkatachalam, T.K., Qazi, S., Samuel, P., Uckun, F.M. Bioorg. Med. Chem. Lett. (2003) [Pubmed]
  7. Isolation and characterization of IgE receptors from rat intestinal mucosal mast cells. Swieter, M., Chan, B.M., Rimmer, C., McNeill, K., Froese, A., Befus, D. Eur. J. Immunol. (1989) [Pubmed]
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