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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Mononegavirales

  • A new recombinant vesicular stomatitis virus (rVSV) that expresses green fluorescent protein (GFP) on the cytoplasmic domain of the VSV glycoprotein (G protein) was used in the mouse as a model for studying brain infections by a member of the Mononegavirales order that can cause permanent changes in behavior [1].
  • Highly conserved domains were identified in the RNA-dependent RNA polymerase (L) between TV and other viruses within the order of Mononegavirales, and homology was found in particular with members of the Rhabdoviridae [2].

High impact information on Mononegavirales

  • The presence of several conserved linear domains commonly found within L proteins of other members of the order Mononegavirales identified this protein as the RNA-dependent RNA polymerase of Ebola virus [3].
  • This study represents the first comprehensive functional assessment of the accessary C protein for Mononegavirales [4].
  • Alignment of the Mokola virus L protein with other polymerases from the virus order Mononegavirales defined three domains: a divergent NH2-terminal domain, a highly conserved central domain carrying most of the functional motifs and a COOH-terminal domain with alternating conserved and divergent regions [5].
  • As in other families of the Mononegavirales, the active polymerase complex of BDV is composed of the polymerase (L), the nucleoprotein (N) and the phosphoprotein (P) [6].


  1. Relative neurotropism of a recombinant rhabdovirus expressing a green fluorescent envelope glycoprotein. van den Pol, A.N., Dalton, K.P., Rose, J.K. J. Virol. (2002) [Pubmed]
  2. Identification and partial characterization of Taastrup virus: a newly identified member species of the Mononegavirales. Bock, J.O., Lundsgaard, T., Pedersen, P.A., Christensen, L.S. Virology (2004) [Pubmed]
  3. Characterization of the L gene and 5' trailer region of Ebola virus. Volchkov, V.E., Volchkova, V.A., Chepurnov, A.A., Blinov, V.M., Dolnik, O., Netesov, S.V., Feldmann, H. J. Gen. Virol. (1999) [Pubmed]
  4. Sendai virus C proteins are categorically nonessential gene products but silencing their expression severely impairs viral replication and pathogenesis. Kurotani, A., Kiyotani, K., Kato, A., Shioda, T., Sakai, Y., Mizumoto, K., Yoshida, T., Nagai, Y. Genes Cells (1998) [Pubmed]
  5. The complete Mokola virus genome sequence: structure of the RNA-dependent RNA polymerase. Le Mercier, P., Jacob, Y., Tordo, N. J. Gen. Virol. (1997) [Pubmed]
  6. Novel insights into the regulation of the viral polymerase complex of neurotropic Borna disease virus. Schneider, U. Virus Res. (2005) [Pubmed]
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