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L  -  RNA polymerase

Infectious hematopoietic necrosis virus

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Disease relevance of L

  • The virus is enzootic throughout western North America and has spread to Asia and Europe. A full-length cDNA of the IHNV antigenome (pIHNV-Pst) was assembled from subgenomic overlapping cDNA fragments and cloned in a transcription plasmid between the T7 RNA polymerase promoter and the autocatalytic hepatitis delta virus ribozyme [1].
  • Transcription in vitro by the RNA polymerase of infectious haematopoietic necrosis virus (IHNV), a salmonid rhabdovirus, was investigated using different reaction conditions to maximize RNA synthesis [2].

High impact information on L


Other interactions of L

  • This region contains a gene coding for a protein, identified as nonvirion protein (NV), and the gene coding for the RNA polymerase (L) [4].


  1. Recovery of NV knockout infectious hematopoietic necrosis virus expressing foreign genes. Biacchesi, S., Thoulouze, M.I., Béarzotti, M., Yu, Y.X., Brémont, M. J. Virol. (2000) [Pubmed]
  2. Transcription in vitro of infectious haematopoietic necrosis virus, a fish rhabdovirus. Kurath, G., Leong, J.C. J. Gen. Virol. (1987) [Pubmed]
  3. Complete genomic sequence of the fish rhabdovirus infectious haematopoietic necrosis virus. Schütze, H., Enzmann, P.J., Kuchling, R., Mundt, E., Niemann, H., Mettenleiter, T.C. J. Gen. Virol. (1995) [Pubmed]
  4. Distant strains of the fish rhabdovirus VHSV maintain a sixth functional cistron which codes for a nonstructural protein of unknown function. Basurco, B., Benmansour, A. Virology (1995) [Pubmed]
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