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Gene Review

C'  -  C' protein

Sendai virus

 
 
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Disease relevance of C'

  • Expression of dsRNA-binding protein NS1A or NS1B from influenza virus, but not C protein from Sendai virus, which does not bind dsRNA, likewise effected polR rescue [1].
  • This study represents the first comprehensive functional assessment of the accessary C protein for Mononegavirales [2].
  • The lack of a C protein-coding region in the P/V gene, the creation of P mRNA by insertion of 2-G residues, and the results of phylogenetic analyses all indicated that TiV is a novel member of the genus Rubulavirus [3].
  • BACKGROUND: The P/C gene of the Sendai virus (SeV), a member of the family Paramyxoviridae, encodes C protein, which plays a crucial role in counteracting the antiviral effect of interferon (IFN) [4].
  • An expression plasmid, ptac-C, was constructed by inserting the cDNA of the coding region of the Sendai virus nonstructural C protein downstream of the tac promoter of E. coli expression plasmid ptac12-Bam [5].
 

High impact information on C'

  • Since the C' protein is encoded in the same reading frame as the C protein but did not initiate from any of the 5' proximal AUGs, the synthesis of the C' protein may start from a non-AUG initiator codon in the P/C gene [6].
  • Characterization of the amino acid residues of sendai virus C protein that are critically involved in its interferon antagonism and RNA synthesis down-regulation [7].
  • In contrast, in cells infected with SeV lacking the AUG114-initiated C protein or containing a single amino acid substitution in the C protein, the level of Stat1 increased and VSV replication was inhibited [8].
  • In addition, the 22,000-dalton C protein mRNA cosedimented on sucrose gradients with the 79,000-dalton P protein mRNA [9].
  • Sendai virus C protein impairs both phosphorylation and dephosphorylation processes of Stat1 [10].
 

Biological context of C'

 

Analytical, diagnostic and therapeutic context of C'

References

  1. Overproduction of double-stranded RNA in vesicular stomatitis virus-infected cells activates a constitutive cell-type-specific antiviral response. Ostertag, D., Hoblitzell-Ostertag, T.M., Perrault, J. J. Virol. (2007) [Pubmed]
  2. Sendai virus C proteins are categorically nonessential gene products but silencing their expression severely impairs viral replication and pathogenesis. Kurotani, A., Kiyotani, K., Kato, A., Shioda, T., Sakai, Y., Mizumoto, K., Yoshida, T., Nagai, Y. Genes Cells (1998) [Pubmed]
  3. Tioman virus, a novel paramyxovirus isolated from fruit bats in Malaysia. Chua, K.B., Wang, L.F., Lam, S.K., Crameri, G., Yu, M., Wise, T., Boyle, D., Hyatt, A.D., Eaton, B.T. Virology (2001) [Pubmed]
  4. Sendai virus C protein physically associates with Stat1. Takeuchi, K., Komatsu, T., Yokoo, J., Kato, A., Shioda, T., Nagai, Y., Gotoh, B. Genes Cells (2001) [Pubmed]
  5. Purification of the Sendai virus nonstructural C protein expressed in E. coli, and preparation of antiserum against C protein. Omata-Yamada, T., Hagiwara, K., Katoh, K., Yamada, H., Iwasaki, K. Arch. Virol. (1988) [Pubmed]
  6. Translation initiation potential of the 5' proximal AUGs of the polycistronic P/C mRNA of Sendai virus. A multipurpose vector for site-specific mutagenesis. Patwardhan, S., Gupta, K.C. J. Biol. Chem. (1988) [Pubmed]
  7. Characterization of the amino acid residues of sendai virus C protein that are critically involved in its interferon antagonism and RNA synthesis down-regulation. Kato, A., Cortese-Grogan, C., Moyer, S.A., Sugahara, F., Sakaguchi, T., Kubota, T., Otsuki, N., Kohase, M., Tashiro, M., Nagai, Y. J. Virol. (2004) [Pubmed]
  8. Sendai virus C proteins counteract the interferon-mediated induction of an antiviral state. Garcin, D., Latorre, P., Kolakofsky, D. J. Virol. (1999) [Pubmed]
  9. In vitro synthesis of the nonstructural C protein of Sendai virus. Dethlefsen, L., Kolakofsky, D. J. Virol. (1983) [Pubmed]
  10. Sendai virus C protein impairs both phosphorylation and dephosphorylation processes of Stat1. Komatsu, T., Takeuchi, K., Yokoo, J., Gotoh, B. FEBS Lett. (2002) [Pubmed]
  11. Paramyxovirus accessory proteins as interferon antagonists. Gotoh, B., Komatsu, T., Takeuchi, K., Yokoo, J. Microbiol. Immunol. (2001) [Pubmed]
  12. Inhibition of the gamma interferon response by a Sendai virus C protein mutant with no STAT1-binding ability. Gotoh, B., Takeuchi, K., Komatsu, T. FEBS Lett. (2004) [Pubmed]
  13. Association of the Sendai virus C protein with nucleocapsids. Yamada, H., Hayata, S., Omata-Yamada, T., Taira, H., Mizumoto, K., Iwasaki, K. Arch. Virol. (1990) [Pubmed]
 
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