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MeSH Review:

Perianal Glands

Morfin, R.F. et al., Nakano, M. et al., Mancini, M.A. et al., Nishikawa, S. et al., Rowlatt, C. et al., et al.

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High impact information on Perianal Glands

Perianal gland tumors appear to be androgen dependent [1].
Whereas in the preputial gland all of the acinar cells exhibit immunoreactivity, in the meibomian and perianal glands only selective cells contain alpha 2u-globulin [2].
Incubation of 5 alpha-[4-14C, 7 beta-2H0.46]dihydrotestosterone (7 microM) and minced canine perianal glands and NADPH (0.2 mM) gave in 5% yield a transformation product with an RF-value of 5 alpha-androstane-3 beta, 7 alpha, 17 beta-triol [3].
These results suggest that increased expression of Mdm2 is an early event in circumanal gland tumorigenesis, and may be present in the absence of nuclear p53 protein accumulation [4].
CK 14 was found in basal cell-derived neoplasias and in sebaceous and perianal gland tumours [5].

Associations of Perianal Glands with chemical compounds

Carcinoma of the perianal gland and associated structures in 1,2-dimethylhydrazine treated mice [6].
Effects of mithramycin on transplantable canine perianal gland carcinoma (CAC-9) in nude mice: biochemical, histomorphometric, and ultrastructural investigations [7].

References

Hormone-dependent neoplasms of the canine perianal gland. Hayes, H.M., Wilson, G.P. Cancer Res. (1977) [Pubmed]
Alpha 2u-globulin in modified sebaceous glands with pheromonal functions: localization of the protein and its mRNA in preputial, meibomian, and perianal glands. Mancini, M.A., Majumdar, D., Chatterjee, B., Roy, A.K. J. Histochem. Cytochem. (1989) [Pubmed]
C19-Steroid metabolism by canine prostate, epididymis and perianal glands. Application of the twin-ion technique of gas chromatography/mass spectrometry to establish 7 alpha-hydroxylation. Morfin, R.F., Leav, I., Orr, J.C., Picart, D., Ofner, P. Eur. J. Biochem. (1980) [Pubmed]
Protein expression of Mdm2 and p53 in hyperplastic and neoplastic lesions of the canine circumanal gland. Nakano, M., Taura, Y., Inoue, M. J. Comp. Pathol. (2005) [Pubmed]
A cytokeratin profile of canine epithelial skin tumours. Walter, J. J. Comp. Pathol. (2000) [Pubmed]
Carcinoma of the perianal gland and associated structures in 1,2-dimethylhydrazine treated mice. Rowlatt, C., Defries, E.A., Sheriff, M.U. Toxicol. Lett. (1981) [Pubmed]
Effects of mithramycin on transplantable canine perianal gland carcinoma (CAC-9) in nude mice: biochemical, histomorphometric, and ultrastructural investigations. Nishikawa, S., Rosol, T.J., Capen, C.C. Vet. Pathol. (1986) [Pubmed]

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