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Disease relevance of Cystoviridae


High impact information on Cystoviridae

  • Thus, P4 proteins of Cystoviridae exhibit extensive similarity to hexameric helicases and are simple models for studying viral packaging motor mechanisms [3].
  • Based on these and earlier observations, we propose a model of transcriptional polarity in Cystoviridae controlled on two independent levels: Pol affinity to plus-strand initiation sites and accessibility of these sites to the Pol in a single-stranded form [4].
  • The packaging of genomic RNA in members of the Cystoviridae is performed by P4, a hexameric protein with NTPase activity [5].


  1. Cooperative mechanism of RNA packaging motor. Lísal, J., Tuma, R. J. Biol. Chem. (2005) [Pubmed]
  2. Virus particles and receptor interaction monitored by fluorescence spectroscopy. Alimova, A., Katz, A., Podder, R., Minko, G., Wei, H., Berriman, J., Alfano, R.R., Gottlieb, P. Photochem. Photobiol. (2005) [Pubmed]
  3. RNA packaging device of double-stranded RNA bacteriophages, possibly as simple as hexamer of P4 protein. Kainov, D.E., Pirttimaa, M., Tuma, R., Butcher, S.J., Thomas, G.J., Bamford, D.H., Makeyev, E.V. J. Biol. Chem. (2003) [Pubmed]
  4. Two distinct mechanisms ensure transcriptional polarity in double-stranded RNA bacteriophages. Yang, H., Makeyev, E.V., Butcher, S.J., Gaidelyte, A., Bamford, D.H. J. Virol. (2003) [Pubmed]
  5. Order and disorder in crystals of hexameric NTPases from dsRNA bacteriophages. Mancini, E.J., Grimes, J.M., Malby, R., Sutton, G.C., Kainov, D.E., Juuti, J.T., Makeyev, E.V., Tuma, R., Bamford, D.H., Stuart, D.I. Acta Crystallogr. D Biol. Crystallogr. (2003) [Pubmed]
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