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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Carmovirus


High impact information on Carmovirus

  • Excluding two unique open reading frames (ORFs) encoding p23 and p25, the ORFs encode proteins with high amino acid similarity to those of carmoviruses [3].
  • This is different from another virus in the genus Carmovirus, Turnip crinkle virus (TCV), the CP of which strongly suppresses dsRNA-induced PTGS [4].
  • The sequence analysis of p8 revealed two unique nuclear localization signals (NLSs), which were not conserved within p8 homologues of other viruses in the genus Carmovirus [5].
  • In vivo detection, RNA-binding properties and characterization of the RNA-binding domain of the p7 putative movement protein from carnation mottle carmovirus (CarMV) [6].
  • These experiments provide further evidence that both MP genes encoded by Carmoviruses must function in trans in the same cell in order to mediate cell-to-cell movement [7].

Chemical compound and disease context of Carmovirus


Gene context of Carmovirus

  • Amino acid sequence comparisons revealed that the proteins encoded by ORFs 2, 3 and 4 are more similar to the corresponding gene products of Carnation mottle virus than to those of other carmoviruses, whereas the p27 and the CP show higher identity with the equivalent proteins of Saguaro cactus virus [9].
  • In addition, only p7 showed similarity with movement proteins of carmoviruses whereas p6 (as p13) has no viral (or other) homologs [10].
  • Like Carnation mottle virus (CarMV), the 5'-proximal three ORFs encode a 26 kDa protein (p26) and two readthrough proteins, i.e. an 85 kDa putative RNA replicase (p85) and a 99 kDa protein (p99) [11].
  • The turnip crinkle carmovirus (TCV) coat protein (CP) is folded into R (RNA-binding), S (shell), and P (protruding) domains [12].


  1. Mechanism of RNA recombination in carmo- and tombusviruses: evidence for template switching by the RNA-dependent RNA polymerase in vitro. Cheng, C.P., Nagy, P.D. J. Virol. (2003) [Pubmed]
  2. A novel RNA mycovirus in a hypovirulent isolate of the plant pathogen Diaporthe ambigua. Preisig, O., Moleleki, N., Smit, W.A., Wingfield, B.D., Wingfield, M.J. J. Gen. Virol. (2000) [Pubmed]
  3. Complete nucleotide sequence and genome organization of hibiscus chlorotic ringspot virus, a new member of the genus Carmovirus: evidence for the presence and expression of two novel open reading frames. Huang, M., Koh, D.C., Weng, L.J., Chang, M.L., Yap, Y.K., Zhang, L., Wong, S.M. J. Virol. (2000) [Pubmed]
  4. Host-induced avirulence of hibiscus chlorotic ringspot virus mutants correlates with reduced gene-silencing suppression activity. Meng, C., Chen, J., Peng, J., Wong, S.M. J. Gen. Virol. (2006) [Pubmed]
  5. Nuclear localization of turnip crinkle virus movement protein p8. Cohen, Y., Qu, F., Gisel, A., Morris, T.J., Zambryski, P.C. Virology (2000) [Pubmed]
  6. In vivo detection, RNA-binding properties and characterization of the RNA-binding domain of the p7 putative movement protein from carnation mottle carmovirus (CarMV). Marcos, J.F., Vilar, M., Pérez-Payá, E., Pallás, V. Virology (1999) [Pubmed]
  7. Cell-to-cell movement of turnip crinkle virus is controlled by two small open reading frames that function in trans. Li, W.Z., Qu, F., Morris, T.J. Virology (1998) [Pubmed]
  8. The genomic sequence of cardamine chlorotic fleck carmovirus. Skotnicki, M.L., Mackenzie, A.M., Torronen, M., Gibbs, A.J. J. Gen. Virol. (1993) [Pubmed]
  9. Complete nucleotide sequence and genome organization of Pelargonium flower break virus. Rico, P., Hernández, C. Arch. Virol. (2004) [Pubmed]
  10. Complete nucleotide sequence and genome organization of Pelargonium line pattern virus and its relationship with the family Tombusviridae. Castaño, A., Hernández, C. Arch. Virol. (2005) [Pubmed]
  11. The nucleotide sequence and genome organization of Japanese iris necrotic ring virus, a new species in the genus Carmovirus. Takemoto, Y., Kanehira, T., Shinohara, M., Yamashita, S., Hibi, T. Arch. Virol. (2000) [Pubmed]
  12. Mutational analyses of the putative calcium binding site and hinge of the turnip crinkle virus coat protein. Lin, B., Heaton, L.A. Virology (1999) [Pubmed]
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