High impact information on Combinatorial Chemistry Techniques

• Combinatorial chemistry techniques applied to nonpeptide integrin antagonists [1].
• The widespread use of HTS and combinatorial chemistry techniques has led to the generation of large amounts of pharmacological data, which, in turn, has catalyzed the development of computational methods designed to reduce the time and cost in identifying molecules suitable for pharmaceutical development [2].
• Because many of these microtubule associated proteins have an ATP binding site, both computer-aided design and combinatorial chemistry techniques can be used to make agents to interfere with their function analogous to imatinib mesylate (Gleevec) [3].
• This synthetic method could be very useful for drug discovery of selectin antagonists using combinatorial chemistry techniques [4].

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