High impact information on Computer-Aided Design

• Computer-assisted design of studies using routine clinical data. Analyzing the association of prednisone and cholesterol [1].
• To elucidate the three-dimensional structure of the enzyme for use in computer-aided design of therapeutically relevant enzyme inhibitors, we investigated the participation of cysteine residues in disulfide linkages in a purified murine recombinant enzyme [2].
• The system is structured around CAD (Computer Aided Design) principles [3].
• RESULTS: By applying computer-aided design methods guided by X-ray structures, we designed and synthesized several MHC class I ligands, based on known peptide ligands, in which the tricyclic, aromatic compound phenanthridine replaced the central amino acids of the peptides [4].
• Computer-assisted design of selective imidazole inhibitors for cytochrome p450 enzymes [5].

Anatomical context of Computer-Aided Design

• After three dimensional reconstruction of magnetic resonance imaging of the thoracic cavity and vascular remnants of the recipient, study of anatomic fit was done using the reconstructed thoracic model and three dimensional computer aided design (CAD) model [6].
• A geometric model of a human middle ear was constructed in a computer-aided design (CAD) environment with particular attention to geometry and microanatomy [7].
• The problems of shaping a stable alveolar ridge form favorable for prosthodontic treatment by the various methods of ridge augmentation raise the question of whether computer-aided design (CAD) may be used for geometric modeling of the implant [8].

Associations of Computer-Aided Design with chemical compounds

• Mean gentamicin excretion curves were calculated by a computer-aided design program (SIAM) for the 2 cements [9].
• Based on the structure of FKBP12 complexed with FK506 or rapamycin, with computer-aided design, two neurotrophic ligands, (3R)-4-(p-Toluenesulfonyl)-1,4-thiazane-3-carboxylic acid-L-Leucine ethyl ester and (3R)-4-(p-Toluenesulfonyl)-1,4-thiazane-3-carboxylic acid-L-phenylalanine benzyl ester, were designed and synthesized [10].
• Computer-aided design and activity prediction of leucine aminopeptidase inhibitors [11].
• Computer-aided design (CAD) of Mn(II) complexes: superoxide dismutase mimetics with catalytic activity exceeding the native enzyme [12].
• The selected systems were two CAD-CAM ceramics; Cercon and Vita Mark II and one pressable system; (IPS)Empress 2 for layering technique [13].

Gene context of Computer-Aided Design

• In this study non-peptidic HDM2 (the human homologue of MDM2) inhibitors were obtained by computer-aided design and subsequently synthesized by chemical method [14].
• Computer-aided design of selective COX-2 inhibitors: comparative molecular field analysis, comparative molecular similarity indices analysis, and docking studies of some 1,2-diarylimidazole derivatives [15].
• Computer-assisted design and synthesis of novel aldose reductase inhibitors [16].
• The development of the SMS system relies heavily on recent advances in technology, e.g., software modeling and computer-aided design [17].
• Computer-aided design of chiral ligands. Part 2. Functionality mapping as a method to identify stereocontrol elements for asymmetric reactions [18].

Analytical, diagnostic and therapeutic context of Computer-Aided Design

• The principles, method, and benefits of combining three-dimensional computed tomography (CT) and computer-aided design/computer-aided manufacture (CAD/CAM) technology for development of custom-designed prostheses are applied in the repair of posttraumatic and congenital facial contour deficiencies [19].
• Different milling modes and characteristic path parameters were evaluated to generate milling paths based on computer-aided design (CAD) geometry data of a cochlear implant and an implantable hearing system [20].
• This paper describes the integration of computer-aided design (CAD) with the design and fabrication of wheelchair seats [21].
• Robust dental systems obtained by computer-aided design and manufacture (CAD/CAM) have been introduced and, in parallel, the strength of the ceramic materials used in fabricating dental crowns has improved [22].
• Rapid prototyping, automatic image processing (computer-aided design (CAD)) and computer-aided manufacturing techniques are opening new and interesting prospects for medical devices and tissue engineering, especially for hard tissues such as bone [23].

References