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Chemical Compound Review

prometryn     6-methylsulfanyl-N,N'- dipropan-2-yl-1,3,5...

Synonyms: Gesagard, Mercasin, Mercazin, Merkazin, Promepin, ...
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Disease relevance of prometryn


Psychiatry related information on prometryn


High impact information on prometryn

  • This initial cell contact is followed by the selectin-mediated rolling of leukocytes on the endothelial cell surface [8].
  • Leukocyte adhesion deficiency II (LAD II) is characterized by the lack of fucosylated glycoconjugates, including selectin ligands, causing immunodeficiency and severe mental and growth retardation [9].
  • Physical positioning of known genes in the area (APOA2 and three selectin genes) outside the linked region suggests a novel locus for FCHL on 1q21-q23 [10].
  • In contrast with the rather mild phenotypes observed in mice deficient in a single selectin gene, the doubly deficient mice present extreme leukocytosis, elevated cytokine levels, and alterations in hematopoiesis [11].
  • Of the several families of adhesion receptors involved in leukocyte-endothelial cell interactions, only the selectins have been shown to initiate leukocyte interaction under physiologic shear; indeed, beta 2 (CD18) intergrins responsible for neutrophil arrest are unable to engage without prior selectin-mediated rolling [12].

Chemical compound and disease context of prometryn


Biological context of prometryn


Anatomical context of prometryn


Associations of prometryn with other chemical compounds


Gene context of prometryn


Analytical, diagnostic and therapeutic context of prometryn

  • To examine whether the superior performance of leukocytes reflects molecular features of native ligands or cellular properties that favor selectin-mediated rolling, we coupled structurally defined selectin ligands to microspheres or K562 cells and compared their rolling on P-selectin [34].
  • The purpose of the present study was to assess the efficacy of a selectin blocker (CY 1503) given as an adjunct to thrombolytic therapy to interfere with the inflammatory response after ischemia-reperfusion and subsequently reduce myocardial infarct size in the electrolytic canine model [35].
  • However, when beta(2)- or selectin-null donor cells are treated with anti-alpha(4) antibodies before their transplantation to normal or selectin-deficient recipients, a dramatic inhibition of homing (>90%) was found [36].
  • In summary, this report provides the first evidence for communication between an inflammatory mediator and adhesion receptors at a molecular level, through selectin receptor ligation allowing permissive SOCE to occur following PAF stimulation of human neutrophils [37].
  • Furthermore, the entry of selectin-ligand-positive T cells into the circulation and their accumulation in the bronchoalveolar lavage fluid indicates that these receptors may contribute to T cell recruitment [38].


  1. The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis. Malý, P., Thall, A., Petryniak, B., Rogers, C.E., Smith, P.L., Marks, R.M., Kelly, R.J., Gersten, K.M., Cheng, G., Saunders, T.L., Camper, S.A., Camphausen, R.T., Sullivan, F.X., Isogai, Y., Hindsgaul, O., von Andrian, U.H., Lowe, J.B. Cell (1996) [Pubmed]
  2. Pharmacology of selectin inhibitors in ischemia/reperfusion states. Lefer, D.J. Annu. Rev. Pharmacol. Toxicol. (2000) [Pubmed]
  3. A critical temporal window for selectin-dependent CD4+ lymphocyte homing and initiation of late-phase inflammation in contact sensitivity. Hwang, J.M., Yamanouchi, J., Santamaria, P., Kubes, P. J. Exp. Med. (2004) [Pubmed]
  4. Prokaryotic peptides that block leukocyte adherence to selectins. Rozdzinski, E., Burnette, W.N., Jones, T., Mar, V., Tuomanen, E. J. Exp. Med. (1993) [Pubmed]
  5. Inhibition of proliferation of normal and transformed neural cells by blood group-related oligosaccharides. Santos-Benito, F.F., Fernández-Mayoralas, A., Martín-Lomas, M., Nieto-Sampedro, M. J. Exp. Med. (1992) [Pubmed]
  6. Insights into leukocyte adhesion deficiency type 2 from a novel mutation in the GDP-fucose transporter gene. Hidalgo, A., Ma, S., Peired, A.J., Weiss, L.A., Cunningham-Rundles, C., Frenette, P.S. Blood (2003) [Pubmed]
  7. Elevated plasma and lung endothelial selectin levels in patients with acute respiratory distress syndrome and a history of chronic alcohol abuse. Burnham, E.L., Moss, M., Harris, F., Brown, L.A. Crit. Care Med. (2004) [Pubmed]
  8. Mechanisms that regulate the function of the selectins and their ligands. Vestweber, D., Blanks, J.E. Physiol. Rev. (1999) [Pubmed]
  9. The gene defective in leukocyte adhesion deficiency II encodes a putative GDP-fucose transporter. Lühn, K., Wild, M.K., Eckhardt, M., Gerardy-Schahn, R., Vestweber, D. Nat. Genet. (2001) [Pubmed]
  10. Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23. Pajukanta, P., Nuotio, I., Terwilliger, J.D., Porkka, K.V., Ylitalo, K., Pihlajamäki, J., Suomalainen, A.J., Syvänen, A.C., Lehtimäki, T., Viikari, J.S., Laakso, M., Taskinen, M.R., Ehnholm, C., Peltonen, L. Nat. Genet. (1998) [Pubmed]
  11. Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins. Frenette, P.S., Mayadas, T.N., Rayburn, H., Hynes, R.O., Wagner, D.D. Cell (1996) [Pubmed]
  12. alpha 4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Berlin, C., Bargatze, R.F., Campbell, J.J., von Andrian, U.H., Szabo, M.C., Hasslen, S.R., Nelson, R.D., Berg, E.L., Erlandsen, S.L., Butcher, E.C. Cell (1995) [Pubmed]
  13. Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates. Koike, T., Kimura, N., Miyazaki, K., Yabuta, T., Kumamoto, K., Takenoshita, S., Chen, J., Kobayashi, M., Hosokawa, M., Taniguchi, A., Kojima, T., Ishida, N., Kawakita, M., Yamamoto, H., Takematsu, H., Suzuki, A., Kozutsumi, Y., Kannagi, R., Kanangi, R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  14. Expression of human alpha(1,3)fucosyltransferase antisense sequences inhibits selectin-mediated adhesion and liver metastasis of colon carcinoma cells. Weston, B.W., Hiller, K.M., Mayben, J.P., Manousos, G.A., Bendt, K.M., Liu, R., Cusack, J.C. Cancer Res. (1999) [Pubmed]
  15. Tumor-microenvironment interactions: the fucose-generating FX enzyme controls adhesive properties of colorectal cancer cells. Zipin, A., Israeli-Amit, M., Meshel, T., Sagi-Assif, O., Yron, I., Lifshitz, V., Bacharach, E., Smorodinsky, N.I., Many, A., Czernilofsky, P.A., Morton, D.L., Witz, I.P. Cancer Res. (2004) [Pubmed]
  16. An endothelial ligand for L-selectin is a novel mucin-like molecule. Lasky, L.A., Singer, M.S., Dowbenko, D., Imai, Y., Henzel, W.J., Grimley, C., Fennie, C., Gillett, N., Watson, S.R., Rosen, S.D. Cell (1992) [Pubmed]
  17. Neuronal protection in stroke by an sLex-glycosylated complement inhibitory protein. Huang, J., Kim, L.J., Mealey, R., Marsh, H.C., Zhang, Y., Tenner, A.J., Connolly, E.S., Pinsky, D.J. Science (1999) [Pubmed]
  18. Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1. Watson, M.L., Kingsmore, S.F., Johnston, G.I., Siegelman, M.H., Le Beau, M.M., Lemons, R.S., Bora, N.S., Howard, T.A., Weissman, I.L., McEver, R.P. J. Exp. Med. (1990) [Pubmed]
  19. Adhesive mechanisms governing interferon-producing cell recruitment into lymph nodes. Diacovo, T.G., Blasius, A.L., Mak, T.W., Cella, M., Colonna, M. J. Exp. Med. (2005) [Pubmed]
  20. The kinetics of L-selectin tethers and the mechanics of selectin-mediated rolling. Alon, R., Chen, S., Puri, K.D., Finger, E.B., Springer, T.A. J. Cell Biol. (1997) [Pubmed]
  21. Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins. Lawrence, M.B., Springer, T.A. Cell (1991) [Pubmed]
  22. The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140. Picker, L.J., Warnock, R.A., Burns, A.R., Doerschuk, C.M., Berg, E.L., Butcher, E.C. Cell (1991) [Pubmed]
  23. Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells. Fuhlbrigge, R.C., Kieffer, J.D., Armerding, D., Kupper, T.S. Nature (1997) [Pubmed]
  24. Absence of trauma-induced leukocyte rolling in mice deficient in both P-selectin and intercellular adhesion molecule 1. Kunkel, E.J., Jung, U., Bullard, D.C., Norman, K.E., Wolitzky, B.A., Vestweber, D., Beaudet, A.L., Ley, K. J. Exp. Med. (1996) [Pubmed]
  25. A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature. Wong, J., Johnston, B., Lee, S.S., Bullard, D.C., Smith, C.W., Beaudet, A.L., Kubes, P. J. Clin. Invest. (1997) [Pubmed]
  26. Prevention of leukocyte migration to inflamed skin with a novel fluorosugar modifier of cutaneous lymphocyte-associated antigen. Dimitroff, C.J., Kupper, T.S., Sackstein, R. J. Clin. Invest. (2003) [Pubmed]
  27. Memory B lymphocytes from secondary lymphoid organs interact with E-selectin through a novel glycoprotein ligand. Montoya, M.C., Holtmann, K., Snapp, K.R., Borges, E., Sánchez-Madrid, F., Luscinskas, F.W., Kansas, G., Vestweber, D., de Landázuri, M.O. J. Clin. Invest. (1999) [Pubmed]
  28. The selectin GMP-140 binds to sialylated, fucosylated lactosaminoglycans on both myeloid and nonmyeloid cells. Zhou, Q., Moore, K.L., Smith, D.F., Varki, A., McEver, R.P., Cummings, R.D. J. Cell Biol. (1991) [Pubmed]
  29. The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing. Homeister, J.W., Thall, A.D., Petryniak, B., Malý, P., Rogers, C.E., Smith, P.L., Kelly, R.J., Gersten, K.M., Askari, S.W., Cheng, G., Smithson, G., Marks, R.M., Misra, A.K., Hindsgaul, O., von Andrian, U.H., Lowe, J.B. Immunity (2001) [Pubmed]
  30. Specialized contributions by alpha(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels. Weninger, W., Ulfman, L.H., Cheng, G., Souchkova, N., Quackenbush, E.J., Lowe, J.B., von Andrian, U.H. Immunity (2000) [Pubmed]
  31. Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1. Mazo, I.B., Gutierrez-Ramos, J.C., Frenette, P.S., Hynes, R.O., Wagner, D.D., von Andrian, U.H. J. Exp. Med. (1998) [Pubmed]
  32. CD66 nonspecific cross-reacting antigens are involved in neutrophil adherence to cytokine-activated endothelial cells. Kuijpers, T.W., Hoogerwerf, M., van der Laan, L.J., Nagel, G., van der Schoot, C.E., Grunert, F., Roos, D. J. Cell Biol. (1992) [Pubmed]
  33. Rolling and transient tethering of leukocytes on antibodies reveal specializations of selectins. Chen, S., Alon, R., Fuhlbrigge, R.C., Springer, T.A. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  34. Distinct molecular and cellular contributions to stabilizing selectin-mediated rolling under flow. Yago, T., Leppänen, A., Qiu, H., Marcus, W.D., Nollert, M.U., Zhu, C., Cummings, R.D., McEver, R.P. J. Cell Biol. (2002) [Pubmed]
  35. Adjunctive selectin blockade successfully reduces infarct size beyond thrombolysis in the electrolytic canine coronary artery model. Silver, M.J., Sutton, J.M., Hook, S., Lee, P., Malycky, J.L., Phillips, M.L., Ellis, S.G., Topol, E.J., Nicolini, F.A. Circulation (1995) [Pubmed]
  36. Molecular pathways in bone marrow homing: dominant role of alpha(4)beta(1) over beta(2)-integrins and selectins. Papayannopoulou, T., Priestley, G.V., Nakamoto, B., Zafiropoulos, V., Scott, L.M. Blood (2001) [Pubmed]
  37. E-selectin permits communication between PAF receptors and TRPC channels in human neutrophils. McMeekin, S.R., Dransfield, I., Rossi, A.G., Haslett, C., Walker, T.R. Blood (2006) [Pubmed]
  38. Lymphocyte recruitment and the kinetics of adhesion receptor expression during the pulmonary immune response to particulate antigen. Wolber, F.M., Curtis, J.L., Milik, A.M., Fields, T., Seitzman, G.D., Kim, K., Kim, S., Sonstein, J., Stoolman, L.M. Am. J. Pathol. (1997) [Pubmed]
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