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Chemical Compound Review

prometryn     6-methylsulfanyl-N,N'- dipropan-2-yl-1,3,5...

Synonyms: Gesagard, Mercasin, Mercazin, Merkazin, Promepin, ...
 
 
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Disease relevance of prometryn

 

Psychiatry related information on prometryn

 

High impact information on prometryn

  • This initial cell contact is followed by the selectin-mediated rolling of leukocytes on the endothelial cell surface [8].
  • Leukocyte adhesion deficiency II (LAD II) is characterized by the lack of fucosylated glycoconjugates, including selectin ligands, causing immunodeficiency and severe mental and growth retardation [9].
  • Physical positioning of known genes in the area (APOA2 and three selectin genes) outside the linked region suggests a novel locus for FCHL on 1q21-q23 [10].
  • In contrast with the rather mild phenotypes observed in mice deficient in a single selectin gene, the doubly deficient mice present extreme leukocytosis, elevated cytokine levels, and alterations in hematopoiesis [11].
  • Of the several families of adhesion receptors involved in leukocyte-endothelial cell interactions, only the selectins have been shown to initiate leukocyte interaction under physiologic shear; indeed, beta 2 (CD18) intergrins responsible for neutrophil arrest are unable to engage without prior selectin-mediated rolling [12].
 

Chemical compound and disease context of prometryn

 

Biological context of prometryn

 

Anatomical context of prometryn

 

Associations of prometryn with other chemical compounds

 

Gene context of prometryn

 

Analytical, diagnostic and therapeutic context of prometryn

  • To examine whether the superior performance of leukocytes reflects molecular features of native ligands or cellular properties that favor selectin-mediated rolling, we coupled structurally defined selectin ligands to microspheres or K562 cells and compared their rolling on P-selectin [34].
  • The purpose of the present study was to assess the efficacy of a selectin blocker (CY 1503) given as an adjunct to thrombolytic therapy to interfere with the inflammatory response after ischemia-reperfusion and subsequently reduce myocardial infarct size in the electrolytic canine model [35].
  • However, when beta(2)- or selectin-null donor cells are treated with anti-alpha(4) antibodies before their transplantation to normal or selectin-deficient recipients, a dramatic inhibition of homing (>90%) was found [36].
  • In summary, this report provides the first evidence for communication between an inflammatory mediator and adhesion receptors at a molecular level, through selectin receptor ligation allowing permissive SOCE to occur following PAF stimulation of human neutrophils [37].
  • Furthermore, the entry of selectin-ligand-positive T cells into the circulation and their accumulation in the bronchoalveolar lavage fluid indicates that these receptors may contribute to T cell recruitment [38].

References

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  12. alpha 4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Berlin, C., Bargatze, R.F., Campbell, J.J., von Andrian, U.H., Szabo, M.C., Hasslen, S.R., Nelson, R.D., Berg, E.L., Erlandsen, S.L., Butcher, E.C. Cell (1995) [Pubmed]
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  17. Neuronal protection in stroke by an sLex-glycosylated complement inhibitory protein. Huang, J., Kim, L.J., Mealey, R., Marsh, H.C., Zhang, Y., Tenner, A.J., Connolly, E.S., Pinsky, D.J. Science (1999) [Pubmed]
  18. Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1. Watson, M.L., Kingsmore, S.F., Johnston, G.I., Siegelman, M.H., Le Beau, M.M., Lemons, R.S., Bora, N.S., Howard, T.A., Weissman, I.L., McEver, R.P. J. Exp. Med. (1990) [Pubmed]
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  21. Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins. Lawrence, M.B., Springer, T.A. Cell (1991) [Pubmed]
  22. The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140. Picker, L.J., Warnock, R.A., Burns, A.R., Doerschuk, C.M., Berg, E.L., Butcher, E.C. Cell (1991) [Pubmed]
  23. Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells. Fuhlbrigge, R.C., Kieffer, J.D., Armerding, D., Kupper, T.S. Nature (1997) [Pubmed]
  24. Absence of trauma-induced leukocyte rolling in mice deficient in both P-selectin and intercellular adhesion molecule 1. Kunkel, E.J., Jung, U., Bullard, D.C., Norman, K.E., Wolitzky, B.A., Vestweber, D., Beaudet, A.L., Ley, K. J. Exp. Med. (1996) [Pubmed]
  25. A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature. Wong, J., Johnston, B., Lee, S.S., Bullard, D.C., Smith, C.W., Beaudet, A.L., Kubes, P. J. Clin. Invest. (1997) [Pubmed]
  26. Prevention of leukocyte migration to inflamed skin with a novel fluorosugar modifier of cutaneous lymphocyte-associated antigen. Dimitroff, C.J., Kupper, T.S., Sackstein, R. J. Clin. Invest. (2003) [Pubmed]
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  28. The selectin GMP-140 binds to sialylated, fucosylated lactosaminoglycans on both myeloid and nonmyeloid cells. Zhou, Q., Moore, K.L., Smith, D.F., Varki, A., McEver, R.P., Cummings, R.D. J. Cell Biol. (1991) [Pubmed]
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  30. Specialized contributions by alpha(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels. Weninger, W., Ulfman, L.H., Cheng, G., Souchkova, N., Quackenbush, E.J., Lowe, J.B., von Andrian, U.H. Immunity (2000) [Pubmed]
  31. Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1. Mazo, I.B., Gutierrez-Ramos, J.C., Frenette, P.S., Hynes, R.O., Wagner, D.D., von Andrian, U.H. J. Exp. Med. (1998) [Pubmed]
  32. CD66 nonspecific cross-reacting antigens are involved in neutrophil adherence to cytokine-activated endothelial cells. Kuijpers, T.W., Hoogerwerf, M., van der Laan, L.J., Nagel, G., van der Schoot, C.E., Grunert, F., Roos, D. J. Cell Biol. (1992) [Pubmed]
  33. Rolling and transient tethering of leukocytes on antibodies reveal specializations of selectins. Chen, S., Alon, R., Fuhlbrigge, R.C., Springer, T.A. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  34. Distinct molecular and cellular contributions to stabilizing selectin-mediated rolling under flow. Yago, T., Leppänen, A., Qiu, H., Marcus, W.D., Nollert, M.U., Zhu, C., Cummings, R.D., McEver, R.P. J. Cell Biol. (2002) [Pubmed]
  35. Adjunctive selectin blockade successfully reduces infarct size beyond thrombolysis in the electrolytic canine coronary artery model. Silver, M.J., Sutton, J.M., Hook, S., Lee, P., Malycky, J.L., Phillips, M.L., Ellis, S.G., Topol, E.J., Nicolini, F.A. Circulation (1995) [Pubmed]
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  37. E-selectin permits communication between PAF receptors and TRPC channels in human neutrophils. McMeekin, S.R., Dransfield, I., Rossi, A.G., Haslett, C., Walker, T.R. Blood (2006) [Pubmed]
  38. Lymphocyte recruitment and the kinetics of adhesion receptor expression during the pulmonary immune response to particulate antigen. Wolber, F.M., Curtis, J.L., Milik, A.M., Fields, T., Seitzman, G.D., Kim, K., Kim, S., Sonstein, J., Stoolman, L.M. Am. J. Pathol. (1997) [Pubmed]
 
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