Disease relevance of Genetic Load

• The contribution made by one gene in particular, GJB2, to the genetic load of SNHL has strongly affected the assessment and care of children with hearing loss [1].

High impact information on Genetic Load

• Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility [2].
• Previous studies have usually considered all congenital anomalies (ICD 740-759) as part of the genetic load, but only those judged to fit into one of the above categories were included in the present study [3].
• Both ADHD and alcohol dependence have a high genetic load and might even share overlapping sources of genetic liability [4].
• This implies that there is an increased genetic load defined by specific alleles of both MHC and TCR genes [5].
• A short discussion on a possible genetic load by therapy with Trenimon in man concludes this review [6].

Associations of Genetic Load with chemical compounds

• One can imagine that the species survived to the increase of genetic load caused by the retroviral invasion because restrictive alleles of flamenco were selected [7].

Gene context of Genetic Load

• Two genes that make appreciable contributions to the autosomal recessive non-syndromic deafness (ARNSD) genetic load will be reviewed, GJB2 and SLC26A4 [8].
• Genetic load may also play a role, but presence of epilepsy could be a protective factor [9].

References