Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

MeSH Review:

Tylophora

Yamashiro, T. et al., Abe, F. et al., Manjula, S. et al., Ganguly, T. et al., Ganguly, T. et al., et al.

Ganguly, Sainis, Ganguly, Badheka, Sainis,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Tylophora

Molecular phylogenetic analyses of Vincetoxicum and Tylophora (Apocynaceae-Asclepiadoideae) were conducted based on the nucleotide sequences of cpDNA (two intergenic spacers of trnL (UAA)-trnF (GAA) and psbA-trnH and three introns, i.e., atpF, trnG (UCC) and trnL (UAA)), and nrDNA (ITS and ETS regions) [1].
Five new glycosides of 14,15-seco- and 13,14:15-diseco-type pregnanes, including a new pregnane, 2 alpha-hydroxyhirundigenin, were isolated, in addition to one known glycoside, cynatratoside B, from the roots of Tylophora tanakae Maxim [2].
Antiallergic activity of tylogenin, a novel steroidal compound from Tylophora sylvatica [3].
A novel steroid from Tylophora atrofolliculata Metc [4].
Induction of apoptosis in a human erythroleukemic cell line K562 by tylophora alkaloids involves release of cytochrome c and activation of caspase 3 [5].

Associations of Tylophora with chemical compounds

Mature leaf explant derived callus of Tylophora indica (Burm. f.) Merrill yielded somatic embryos on MS medium supplied with BA(1-2 mg/L) or kinetin(1-5 mg/L) or kinetin/BA (1-2 mg/L) used along with IAA(0.1-1 mg/L) [6].

Gene context of Tylophora

Immunomodulatory effect of Tylophora indica on Con A induced lymphoproliferation [7].
However, the tylophora alkaloids could not suppress primary humoral (IgM) immune response to SRBC in mice at the same dose [8].

References

Molecular phylogeny of Vincetoxicum (Apocynaceae-Asclepiadoideae) based on the nucleotide sequences of cpDNA and nrDNA. Yamashiro, T., Fukuda, T., Yokoyama, J., Maki, M. Mol. Phylogenet. Evol. (2004) [Pubmed]
Glycosides of 14,15-seco- and 13,14:14,15-disecopregnanes from the roots of Tylophora tanakae. Abe, F., Hirokawa, M., Yamauchi, T., Honda, K., Hayashi, N., Nishida, R. Chem. Pharm. Bull. (1999) [Pubmed]
Antiallergic activity of tylogenin, a novel steroidal compound from Tylophora sylvatica. Gnabre, J.N., Halonen, M.J., Martin, D.G., Pinnas, J.L. Int. J. Immunopharmacol. (1994) [Pubmed]
A novel steroid from Tylophora atrofolliculata Metc. Huang, X.S., Yu, S.S., Liang, X.T., Li, N. Journal of Asian natural products research. (2002) [Pubmed]
Induction of apoptosis in a human erythroleukemic cell line K562 by tylophora alkaloids involves release of cytochrome c and activation of caspase 3. Ganguly, T., Khar, A. Phytomedicine (2002) [Pubmed]
Somatic embryogenesis from leaf derived callus of Tylophora indica (Burm. f.) Merrill. Manjula, S., Job, A., Nair, G.M. Indian J. Exp. Biol. (2000) [Pubmed]
Immunomodulatory effect of Tylophora indica on Con A induced lymphoproliferation. Ganguly, T., Badheka, L.P., Sainis, K.B. Phytomedicine (2001) [Pubmed]
Inhibition of cellular immune responses by Tylophora indica in experimental models. Ganguly, T., Sainis, K.B. Phytomedicine (2001) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.