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MeSH Review:

Aspidosperma

Sperling, H. et al., Campos, A.R. et al., Tanaka, J.C. et al., Kozmin, S.A. et al., Quinn, J.F. et al., et al.

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Psychiatry related information on Aspidosperma

PURPOSE: We determined whether an extract from the bark of the tree Aspidosperma quebracho blanco, which is used as a prescription drug to treat erectile dysfunction in some countries, can bind to human penile alpha1 and alpha2-adrenoceptors, and cloned human alpha-adrenoceptor subtypes [1].

High impact information on Aspidosperma

Our approach differs strategically from previous routes and contains built-in flexibility necessary to access many other members of the Aspidosperma family of indole alkaloids [2].
Intramolecular amidofuran cycloadditions across an indole pi-bond: an efficient approach to the aspidosperma and strychnos ABCE core [3].
This reaction provides a convenient entry to the Aspidosperma family of alkaloids, which contain a 3,3-disubstituted carbazole nucleus [4].
We evaluated the antibacterial activities of the crude methanol extract, fractions (I-V) obtained after acid-base extraction and pure compounds from the stem bark of Aspidosperma ramiflorum [5].

Chemical compound and disease context of Aspidosperma

Plants that belong to the genus Aspidosperma (Apocyanaceae) are known to be very rich in indole alkaloids and have an ethnomedical history of use as traditional remedies for erectile dysfunction [6].

References

An extract from the bark of Aspidosperma quebracho blanco binds to human penile alpha-adrenoceptors. Sperling, H., Lorenz, A., Krege, S., Arndt, R., Michel, M.C. J. Urol. (2002) [Pubmed]
An efficient approach to Aspidosperma alkaloids via [4 + 2] cycloadditions of aminosiloxydienes: stereocontrolled total synthesis of (+/-)-tabersonine. Gram-scale catalytic asymmetric syntheses of (+)-tabersonine and (+)-16-methoxytabersonine. Asymmetric syntheses of (+)-aspidospermidine and (-)-quebrachamine. Kozmin, S.A., Iwama, T., Huang, Y., Rawal, V.H. J. Am. Chem. Soc. (2002) [Pubmed]
Intramolecular amidofuran cycloadditions across an indole pi-bond: an efficient approach to the aspidosperma and strychnos ABCE core. Lynch, S.M., Bur, S.K., Padwa, A. Org. Lett. (2002) [Pubmed]
Novel [1,5] sigmatropic rearrangements of cyclohexadienones generated from Fischer carbene complexes. A new strategy for installing the C-20 angular ethyl group in Aspidospermidine alkaloids. Quinn, J.F., Bos, M.E., Wulff, W.D. Org. Lett. (1999) [Pubmed]
Antibacterial activity of indole alkaloids from Aspidosperma ramiflorum. Tanaka, J.C., Silva, C.C., Oliveira, A.J., Nakamura, C.V., Dias Filho, B.P. Braz. J. Med. Biol. Res. (2006) [Pubmed]
Pro-erectile effects of an alkaloidal rich fraction from Aspidosperma ulei root bark in mice. Campos, A.R., Lima, R.C., Uchoa, D.E., Silveira, E.R., Santos, F.A., Rao, V.S. Journal of ethnopharmacology. (2006) [Pubmed]

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