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MeSH Review:

Epsilonretrovirus

Zhang, Z. et al., Lairmore, M.D. et al., Zhang, Z. et al., Rovnak, J. et al., LaPierre, L.A. et al.

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Disease relevance of Epsilonretrovirus

WEHV1, WEHV2, and WDSV are the first examples of retroviruses that encode cyclin homologs [1].

High impact information on Epsilonretrovirus

We have reported that the D-cyclin homologue [retroviral (rv) cyclin] encoded by WDSV rescues yeast conditionally deficient for cyclin synthesis from growth arrest and that WDSV-cyclin mRNA is present in developing tumors [2].
Walleye dermal sarcoma virus cyclin interacts with components of the mediator complex and the RNA polymerase II holoenzyme [3].
The WDSV genome contains three short open reading frames designated orfA, orfB, and orfC in addition to the viral structural genes, gag, pol, and env. orfA and orfB transcripts are detected in tumors by reverse transcription-PCR [4].
A 13 bp region (nt -288 to -275) comprising a putative activator protein-1 element was necessary for maintaining WDSV LTR activity at all temperatures [5].

References

Walleye retroviruses associated with skin tumors and hyperplasias encode cyclin D homologs. LaPierre, L.A., Casey, J.W., Holzschu, D.L. J. Virol. (1998) [Pubmed]
Squamous epithelial proliferation induced by walleye dermal sarcoma retrovirus cyclin in transgenic mice. Lairmore, M.D., Stanley, J.R., Weber, S.A., Holzschu, D.L. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
Walleye dermal sarcoma virus cyclin interacts with components of the mediator complex and the RNA polymerase II holoenzyme. Rovnak, J., Quackenbush, S.L. J. Virol. (2002) [Pubmed]
Walleye dermal sarcoma virus: OrfA N-terminal end inhibits the activity of a reporter gene directed by eukaryotic promoters and has a negative effect on the growth of fish and mammalian cells. Zhang, Z., Martineau, D. J. Virol. (1999) [Pubmed]
Functional characterization of a piscine retroviral promoter. Zhang, Z., Kim, E., Martineau, D. J. Gen. Virol. (1999) [Pubmed]

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