Disease relevance of RNA Processing, Post-Transcriptional

• Absence of post-transcriptional RNA modifications of BCL10 in human malignant mesothelioma and colorectal cancer [1].

High impact information on RNA Processing, Post-Transcriptional

• Our in vivo investigation revealed that expanded GAA.TTC repeats from intron I of the FRDA gene inhibit transcription rather than post-transcriptional RNA processing and also interfere with replication [2].
• Interestingly, in the suprachiasmatic nucleus the proportion of AVPinI to AVP exon C ratio was much higher (12%), suggesting either increased transcription of the AVP gene or changes in posttranscriptional RNA processing [3].
• Between the cox1 and cox2 portions of the transcript, RNA sequence exactly matches gene sequence, excluding the possibility that a standard cox1 termination codon is created by post-transcriptional RNA processing or editing [4].
• Transcriptional regulation and post-transcriptional RNA processing represent essential instruments to generate TRP channel variants with modified properties [5].
• MR mRNA levels did not decrease over comparable time periods, suggesting either a significant lag-time between transcriptional changes and changes in cytoplasmic mRNA pools or stimulus-driven alterations in post-transcriptional RNA processing [6].

Biological context of RNA Processing, Post-Transcriptional

• Applications of recombinant DNA technology in gastrointestinal medicine and hepatology: basic paradigms of molecular cell biology. Part B: eukaryotic gene transcription and post-transcriptional RNA processing [7].

Gene context of RNA Processing, Post-Transcriptional

• Disruption or removal of the small t antigen translation stop codon by post-transcriptional RNA processing could provide a mechanism to achieve the above [8].

References